Literature DB >> 6407169

Permeability of the rat bladder to Cisplatinum under different conditions: comparison with Mitomycin C and Adriamycin.

U Engelmann, G Oelsner, R A Bürger, H Wagner.   

Abstract

In 50 female Sprague-Dawley rats the absorption of Cisplatinum through the bladder wall was studied. Under different conditions, including cystitis and electrocoagulation of the bladder mucosa, the absorption was low and the measureable serum concentrations did not exceed 2.64 micrograms/ml. The influence of Tween 80--a non-ionic surfactant--on the absorption is investigated. The results are compared with those found for Adriamycin and Mitomycin C under identical conditions.

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Year:  1983        PMID： 6407169     DOI： 10.1007/BF00272708

Source DB:  PubMed          Journal:  Urol Res        ISSN： 0300-5623


  18 in total

1.  ELECTRON MICROSCOPIC OBSERVATIONS ON THE COLLAPSED AND DISTENDED MAMMALIAN URINARY BLADDER (TRANSITIONAL EPITHELIUM).

Authors:  W R RICHTER; S M MOIZE
Journal:  J Ultrastruct Res       Date:  1963-08

2.  THE TRANSPORT OF14 C-LABELED NITROGEN MUSTARD N-OXIDE THROUGH CELLULAR MEMBRANE TREATED WITH TWEEN 80 IN VITRO.

Authors:  T YAMADA; Y IWANAMI; T BABA
Journal:  Gan       Date:  1963-06

3.  The effect of surface active agents on the permeability to dye of the plasma membrane of Ehrlich ascites cells.

Authors:  M E HODES; C G PALMER; A WARREN
Journal:  Exp Cell Res       Date:  1960-10       Impact factor: 3.905

4.  An experimental study of the vesical circulation during distension and in cystitis.

Authors:  R M MEHROTRA
Journal:  J Pathol Bacteriol       Date:  1953-07

5.  A light and electron microscopic study of the effects of a single dose of cyclophosphamide on various organs in the rat. I. The urinary bladder.

Authors:  L G Koss
Journal:  Lab Invest       Date:  1967-01       Impact factor: 5.662

6.  Potentiation of drug effect by Tween 80 in Chinese hamster cells resistant to actinomycin D and daunomycin.

Authors:  H Riehm; J L Biedler
Journal:  Cancer Res       Date:  1972-06       Impact factor: 12.701

7.  Reversible alterations of the surface of ascites tumour cells induced by a surface-active substance, Tween 60.

Authors:  A G Malenkov; S A Bogatyreva; V P Bozhkova; E A Modjanova; J M Vasiliev
Journal:  Exp Cell Res       Date:  1967-11       Impact factor: 3.905

8.  Stability of cisplatin in aqueous solution.

Authors:  R F Greene; D C Chatterji; P K Hiranaka; J F Gallelli
Journal:  Am J Hosp Pharm       Date:  1979-01

9.  Adriamycin permeability of the rat bladder under different conditions.

Authors:  U Engelmann; R A Bürger; J H Rumpelt; G H Jacobi
Journal:  J Urol       Date:  1983-04       Impact factor: 7.450

10.  Rapid absorption from the urinary bladder of a series of n-alkyl carbamates: a route for the recirculation of drugs.

Authors:  J W Bridges; N S Sargent; D G Upshall
Journal:  Br J Pharmacol       Date:  1979-06       Impact factor: 8.739
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  1 in total

1.  Serum and tissue levels of platinum after cisplatinum instillation of the rat bladder.

Authors:  H A Wagner; G Groebe; U Engelmann
Journal:  Urol Res       Date:  1988
  1 in total

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