Literature DB >> 8723477

Directly repeated insertion of 9-nucleotide sequence detected in penicillin-binding protein 2B gene of penicillin-resistant Streptococcus pneumoniae.

A Yamane1, H Nakano, Y Asahi, K Ubukata, M Konno.   

Abstract

We investigated the molecular mechanism of 50 penicillin-resistant Streptococcus pneumoniae strains (penicillin: MIC, > or = 0.125 microgram/ml) having neither class A nor class B mutations in the penicillin-binding protein 2B gene (pbp2b). An analysis of the nucleotide sequences of the pbp2b genes from seven strains revealed an unique direct repeat of 9 nucleotides (TGGTATACT) between active-site serine (residue 385) and Ser-X-Asn (residues 442 to 444) motifs. The same insertion was detected in 13 strains.

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Year:  1996        PMID： 8723477      PMCID： PMC163302          DOI： 10.1128/AAC.40.5.1257

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  Direct solid phase sequencing of genomic and plasmid DNA using magnetic beads as solid support.

Authors:  T Hultman; S Ståhl; E Hornes; M Uhlén
Journal:  Nucleic Acids Res       Date:  1989-07-11       Impact factor: 16.971

2.  Nucleotide sequence of the penicillin-binding protein 2B gene of Streptococcus pneumoniae strain R6.

Authors:  C G Dowson; A Hutchison; B G Spratt
Journal:  Nucleic Acids Res       Date:  1989-09-25       Impact factor: 16.971

3.  Diagnosis of sickle cell anemia and beta-thalassemia with enzymatically amplified DNA and nonradioactive allele-specific oligonucleotide probes.

Authors:  R K Saiki; C A Chang; C H Levenson; T C Warren; C D Boehm; H H Kazazian; H A Erlich
Journal:  N Engl J Med       Date:  1988-09-01       Impact factor: 91.245

4.  Alterations in penicillin-binding protein 2B from penicillin-resistant wild-type strains of Streptococcus pneumoniae.

Authors:  A M Smith; K P Klugman
Journal:  Antimicrob Agents Chemother       Date:  1995-04       Impact factor: 5.191

Review 5.  Antimicrobial resistance in Streptococcus pneumoniae: an overview.

Authors:  P C Appelbaum
Journal:  Clin Infect Dis       Date:  1992-07       Impact factor: 9.079

6.  Insertion of an extra amino acid is the main cause of the low affinity of penicillin-binding protein 2 in penicillin-resistant strains of Neisseria gonorrhoeae.

Authors:  J A Brannigan; I A Tirodimos; Q Y Zhang; C G Dowson; B G Spratt
Journal:  Mol Microbiol       Date:  1990-06       Impact factor: 3.501

7.  Rapid detection of the mecA gene in methicillin-resistant staphylococci by enzymatic detection of polymerase chain reaction products.

Authors:  K Ubukata; S Nakagami; A Nitta; A Yamane; S Kawakami; M Sugiura; M Konno
Journal:  J Clin Microbiol       Date:  1992-07       Impact factor: 5.948

8.  Occurrence of a beta-lactam-inducible penicillin-binding protein in methicillin-resistant staphylococci.

Authors:  K Ubukata; N Yamashita; M Konno
Journal:  Antimicrob Agents Chemother       Date:  1985-05       Impact factor: 5.191

9.  Evolution of penicillin resistance in Streptococcus pneumoniae; the role of Streptococcus mitis in the formation of a low affinity PBP2B in S. pneumoniae.

Authors:  C G Dowson; T J Coffey; C Kell; R A Whiley
Journal:  Mol Microbiol       Date:  1993-08       Impact factor: 3.501

10.  Extensive re-modelling of the transpeptidase domain of penicillin-binding protein 2B of a penicillin-resistant South African isolate of Streptococcus pneumoniae.

Authors:  C G Dowson; A Hutchison; B G Spratt
Journal:  Mol Microbiol       Date:  1989-01       Impact factor: 3.501
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  11 in total

1.  Diversity of substitutions within or adjacent to conserved amino acid motifs of penicillin-binding protein 2X in cephalosporin-resistant Streptococcus pneumoniae isolates.

Authors:  Y Asahi; Y Takeuchi; K Ubukata
Journal:  Antimicrob Agents Chemother       Date:  1999-05       Impact factor: 5.191

2.  Unique variations of pbp2b sequences in penicillin-nonsusceptible Streptococcus pneumoniae isolates from Korea.

Authors:  Jin Yang Baek; Kwan Soo Ko; Won Sup Oh; Sook-In Jung; Yeon Sook Kim; Hyun-Ha Chang; Hyuck Lee; Shin Woo Kim; Kyong Ran Peck; Nam Yong Lee; Jae-Hoon Song
Journal:  J Clin Microbiol       Date:  2004-04       Impact factor: 5.948

3.  Emergence of a unique penicillin-resistant Streptococcus pneumoniae serogroup 35 strain.

Authors:  Ronald J Stanek; Mary B Maher; Nancy B Norton; Maurice A Mufson
Journal:  J Clin Microbiol       Date:  2010-10-27       Impact factor: 5.948

4.  Comparative antipneumococcal activities of sulopenem and other drugs.

Authors:  Klaudia Kosowska-Shick; Lois M Ednie; Pamela McGhee; Peter C Appelbaum
Journal:  Antimicrob Agents Chemother       Date:  2009-03-23       Impact factor: 5.191

5.  In vitro activity of tebipenem, a new oral carbapenem antibiotic, against penicillin-nonsusceptible Streptococcus pneumoniae.

Authors:  Reiko Kobayashi; Mami Konomi; Keiko Hasegawa; Miyuki Morozumi; Keisuke Sunakawa; Kimiko Ubukata
Journal:  Antimicrob Agents Chemother       Date:  2005-03       Impact factor: 5.191

6.  Association of a thr-371 substitution in a conserved amino acid motif of penicillin-binding protein 1A with penicillin resistance of Streptococcus pneumoniae.

Authors:  Y Asahi; K Ubukata
Journal:  Antimicrob Agents Chemother       Date:  1998-09       Impact factor: 5.191

7.  Effects of amino acid alterations in penicillin-binding proteins (PBPs) 1a, 2b, and 2x on PBP affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor in 18 clinical isolates of penicillin-susceptible, -intermediate, and -resistant pneumococci.

Authors:  Kensuke Nagai; Todd A Davies; Michael R Jacobs; Peter C Appelbaum
Journal:  Antimicrob Agents Chemother       Date:  2002-05       Impact factor: 5.191

8.  Structure of the low-affinity penicillin-binding protein 5 PBP5fm in wild-type and highly penicillin-resistant strains of Enterococcus faecium.

Authors:  W Zorzi; X Y Zhou; O Dardenne; J Lamotte; D Raze; J Pierre; L Gutmann; J Coyette
Journal:  J Bacteriol       Date:  1996-08       Impact factor: 3.490

9.  Antibiotic susceptibility in relation to penicillin-binding protein genes and serotype distribution of Streptococcus pneumoniae strains responsible for meningitis in Japan, 1999 to 2002.

Authors:  Kimiko Ubukata; Naoko Chiba; Keiko Hasegawa; Reiko Kobayashi; Satoshi Iwata; Keisuke Sunakawa
Journal:  Antimicrob Agents Chemother       Date:  2004-05       Impact factor: 5.191

10.  Complete sequences of six penicillin-binding protein genes from 40 Streptococcus pneumoniae clinical isolates collected in Japan.

Authors:  Yumiko Sanbongi; Takashi Ida; Midori Ishikawa; Yumi Osaki; Hiroshi Kataoka; Takahisa Suzuki; Kumiko Kondo; Fukuichi Ohsawa; Minoru Yonezawa
Journal:  Antimicrob Agents Chemother       Date:  2004-06       Impact factor: 5.191
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