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Literature DB >> 8722175

Boundary and insulator elements in chromosomes.

Abstract

Recent progress in understanding boundary and insulator elements has concentrated on the identification of their protein components. BEAF-32 is a protein present in the scs' element of Drosophila that is also localized to most interband regions and puffs of polytene chromosomes, suggesting a role in the organization of structural chromosomal domains. The suppressor of Hairy-wing and modifier of mdg4 proteins have been characterized as components of the gypsy insulator. The latter seems to play a crucial role in conferring on the insulator its ability to unidirectionally affect enhancer function.

Entities: Disease Gene Species

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Year: 1996 PMID： 8722175 DOI： 10.1016/s0959-437x(96)80049-9

Source DB: PubMed Journal: Curr Opin Genet Dev ISSN： 0959-437X Impact factor: 5.578

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Cited

35 in total

1. Positional enhancer-blocking activity of the chicken beta-globin insulator in transiently transfected cells.

Authors: F Recillas-Targa; A C Bell; G Felsenfeld
Journal: Proc Natl Acad Sci U S A Date: 1999-12-07 Impact factor: 11.205

2. The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites.

Authors: S Rivella; J A Callegari; C May; C W Tan; M Sadelain
Journal: J Virol Date: 2000-05 Impact factor: 5.103

3. Cohabitation of insulators and silencing elements in yeast subtelomeric regions.

Authors: G Fourel; E Revardel; C E Koering; E Gilson
Journal: EMBO J Date: 1999-05-04 Impact factor: 11.598

4. Parental allele-specific chromatin configuration in a boundary-imprinting-control element upstream of the mouse H19 gene.

Authors: S Khosla; A Aitchison; R Gregory; N D Allen; R Feil
Journal: Mol Cell Biol Date: 1999-04 Impact factor: 4.272

5. The chicken beta-globin 5'HS4 boundary element blocks enhancer-mediated suppression of silencing.

Authors: M C Walters; S Fiering; E E Bouhassira; D Scalzo; S Goeke; W Magis; D Garrick; E Whitelaw; D I Martin
Journal: Mol Cell Biol Date: 1999-05 Impact factor: 4.272

6. Ectopic expression of DREF induces DNA synthesis, apoptosis, and unusual morphogenesis in the Drosophila eye imaginal disc: possible interaction with Polycomb and trithorax group proteins.

Authors: F Hirose; N Ohshima; M Shiraki; Y H Inoue; O Taguchi; Y Nishi; A Matsukage; M Yamaguchi
Journal: Mol Cell Biol Date: 2001-11 Impact factor: 4.272

Boundary and insulator elements in chromosomes.

1. Positional enhancer-blocking activity of the chicken beta-globin insulator in transiently transfected cells.

2. The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites.

3. Cohabitation of insulators and silencing elements in yeast subtelomeric regions.

4. Parental allele-specific chromatin configuration in a boundary-imprinting-control element upstream of the mouse H19 gene.

5. The chicken beta-globin 5'HS4 boundary element blocks enhancer-mediated suppression of silencing.

6. Ectopic expression of DREF induces DNA synthesis, apoptosis, and unusual morphogenesis in the Drosophila eye imaginal disc: possible interaction with Polycomb and trithorax group proteins.

7. Interactions between the Su(Hw) and Mod(mdg4) proteins required for gypsy insulator function.

8. Studies of the role of the Drosophila scs and scs' insulators in defining boundaries of a chromosome puff.

9. Condensation by DNA looping facilitates transfer of large DNA molecules into mammalian cells.

10. The gypsy insulator can act as a promoter-specific transcriptional stimulator.