Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Hepatic drug acetylation and oxidation: effects of aging in man.

Literature DB >> 871823

Hepatic drug acetylation and oxidation: effects of aging in man.

F Farah, W Taylor, M D Rawlins, O James.

Abstract

The half lives of acetanilide and isoniazid ("model" substrates for oxidation and acetylation respectively) were measured in populations of young (aged 20-35 years) and elderly (aged over 65 years) people. Whereas acetanilide half lives were significantly longer in the elderly, isoniazid half lives were distributed similarly in both populations. The results suggest that liver function does not decline uniformly with age and that heterozygotes for acetylation do not possess survival advantages during their middle years of life.

Entities: Chemical Disease Species

Mesh：

Substances：
Acetanilides
Isoniazid

Year: 1977 PMID： 871823 PMCID： PMC1631052 DOI： 10.1136/bmj.2.6080.155

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

5 in total

1. Genetic control of isoniazid metabolism in man.

Authors: D A EVANS; K A MANLEY; V A McKUSICK
Journal: Br Med J Date: 1960-08-13

2. The pharmacokinetics of acetanilide and of diphenylhydantoin sodium.

Authors: J L Cunningham; M F Bullen; D A Evans
Journal: Eur J Clin Pharmacol Date: 1974-10-04 Impact factor: 2.953

3. [Contribution to the problem of functional changes in the liver in the aging process. Changes in bromosulphthalein kinetics].

Authors: V Skaunic; V Nerad; J Skaunicová
Journal: Gerontol Clin (Basel) Date: 1968

4. Correlation of subjective side effects with plasma concentrations of nortriptyline.

Authors: M Asberg; B Cronholm; F Sjöqvist; D Tuck
Journal: Br Med J Date: 1970-10-03

5. Genetic control of phenylbutazone metabolism in man.

Authors: J A Whittaker; D A Evans
Journal: Br Med J Date: 1970-11-07

5 in total

25 in total

Review 1. Hepatic drug metabolism and aging.

Authors: C Durnas; C M Loi; B J Cusack
Journal: Clin Pharmacokinet Date: 1990-11 Impact factor: 6.447

Hepatic drug acetylation and oxidation: effects of aging in man.

1. Genetic control of isoniazid metabolism in man.

2. The pharmacokinetics of acetanilide and of diphenylhydantoin sodium.

3. [Contribution to the problem of functional changes in the liver in the aging process. Changes in bromosulphthalein kinetics].

4. Correlation of subjective side effects with plasma concentrations of nortriptyline.

5. Genetic control of phenylbutazone metabolism in man.

Review 1. Hepatic drug metabolism and aging.

2. Influence of age, sex and body weight on the dapsone acetylation phenotype.

Review 3. Drug use in the elderly: a review of problems and special considerations.

4. Pharmacokinetics of isoniazid: influence of age.

5. The treatment of hypertension in the elderly.

6. Benzodiazepines: clinical pharmacology and therapeutic use.

7. Acetylator phenotypes: effect of age.

8. Age related differences in the disposition of acetanilide.

9. Antipyrine disposition and liver size in the elderly.

10. The disposition of antipyrine and its metabolites in young and elderly healthy volunteers.