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Literature DB >> 6714291

Acetylator phenotypes: effect of age.

Abstract

The distribution of acetylator phenotypes in a Hungarian population of 253 Caucasian was studied. The patients were divided into two age groups - the elderly over 60 years, and young below that age. The individuals below the age of 60 years contained an equal proportion of the two acetylator phenotypes. The same distribution was observed in the population as a whole. In the elderly subjects the slow acetylator phenotype was predominant. The finding supports the hypothesis that age has an influence on hepatic drug acetylation rate.

Entities: Species

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Substances：
Sulfamethazine

Year: 1984 PMID： 6714291 DOI： 10.1007/bf00546707

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

7 in total

1. Hepatic drug acetylation and oxidation: effects of aging in man.

Authors: F Farah; W Taylor; M D Rawlins; O James
Journal: Br Med J Date: 1977-07-16

Review 2. Factors influencing antipyrine elimination.

Authors: I H Stevenson
Journal: Br J Clin Pharmacol Date: 1977-06 Impact factor: 4.335

Review 3. Ethnic differences in drug metabolism.

Authors: W Kalow
Journal: Clin Pharmacokinet Date: 1982 Sep-Oct Impact factor: 6.447

4. Role of N-acetyltransferase phenotypes in bladder carcinogenesis: a pharmacogenetic epidemiological approach to bladder cancer.

Authors: R A Cartwright; R W Glashan; H J Rogers; R A Ahmad; D Barham-Hall; E Higgins; M A Kahn
Journal: Lancet Date: 1982-10-16 Impact factor: 79.321

5. Polymorphic acetylation of sulphadimidine in normal and uraemic man.

Authors: T Talseth; K H Landmark
Journal: Eur J Clin Pharmacol Date: 1977 Impact factor: 2.953

Review 6. Clinical pharmacokinetics of isoniazid.

Authors: W W Weber; D W Hein
Journal: Clin Pharmacokinet Date: 1979 Nov-Dec Impact factor: 6.447

7. Ethanol-induced increase in drug acetylation in man and isolated rat liver cells.

Authors: H Olsen; J Mørland
Journal: Br Med J Date: 1978-11-04

7 in total

12 in total

Review 1. Hepatic drug metabolism and aging.

Authors: C Durnas; C M Loi; B J Cusack
Journal: Clin Pharmacokinet Date: 1990-11 Impact factor: 6.447

Acetylator phenotypes: effect of age.

1. Hepatic drug acetylation and oxidation: effects of aging in man.

Review 2. Factors influencing antipyrine elimination.

Review 3. Ethnic differences in drug metabolism.

4. Role of N-acetyltransferase phenotypes in bladder carcinogenesis: a pharmacogenetic epidemiological approach to bladder cancer.

5. Polymorphic acetylation of sulphadimidine in normal and uraemic man.

Review 6. Clinical pharmacokinetics of isoniazid.

7. Ethanol-induced increase in drug acetylation in man and isolated rat liver cells.

Review 1. Hepatic drug metabolism and aging.

Review 2. Physiological changes due to age. Pharmacodynamic changes of drug action and implications for therapy.

3. Influence of age, sex and body weight on the dapsone acetylation phenotype.

4. Pharmacokinetics of isoniazid: influence of age.

5. Distribution of acetylator phenotype in relation to age and sex in Swedish patients. A retrospective study.

6. Ageing and acetylator phenotype as determined by administration of sulphadimidine.

7. Ageing and acetylator phenotype.

Review 8. Drug dosage in the elderly. Is it rational?

9. Pharmacogenetic differences in the inhibitory effect of cimetidine on the metabolism of antipyrine.

10. N-acetylation phenotyping with sulphadimidine in a Turkish population.