OBJECTIVE: To determine the aetiological relationship between human T cell leukaemia virus type-I (HTLV-I) and arthritis, by performing an epidemiological study of the inhabitants of Tsushima, an island northwest of the main island of Kyushu, Japan, which is an endemic area of HTLV-I. METHODS: A total of 7087 people underwent an annual health check, and those with arthropathy had further physical and radiological examinations by rheumatologists. The presence of HTLV-I antibody was determined by the particle agglutinin method, and integration of the proviral DNA in peripheral lymphocytes was confirmed by polymerase chain reaction. RESULTS: HTLV-I was positive in 26.1% of inhabitants; the incidence increased to 37.0% in patients with symptoms of polyarthritis. The prevalence of rheumatoid arthritis (RA) was significantly different between HTLV-I carriers (0.56%) and non-carriers (0.31%). The stage of bone destruction in HTLV-I carriers with articular symptoms was milder than that in RA patients without HTLV-I. The relative risk of HTLV-I infection for polyarthritis was 1.66 (p < 0.05). CONCLUSION: This is the first epidemiological report clarifying the association between HTLV-I and polyarthritis. Our results suggest that this viral infection has a relationship to RA.
OBJECTIVE: To determine the aetiological relationship between human T cell leukaemia virus type-I (HTLV-I) and arthritis, by performing an epidemiological study of the inhabitants of Tsushima, an island northwest of the main island of Kyushu, Japan, which is an endemic area of HTLV-I. METHODS: A total of 7087 people underwent an annual health check, and those with arthropathy had further physical and radiological examinations by rheumatologists. The presence of HTLV-I antibody was determined by the particle agglutinin method, and integration of the proviral DNA in peripheral lymphocytes was confirmed by polymerase chain reaction. RESULTS:HTLV-I was positive in 26.1% of inhabitants; the incidence increased to 37.0% in patients with symptoms of polyarthritis. The prevalence of rheumatoid arthritis (RA) was significantly different between HTLV-I carriers (0.56%) and non-carriers (0.31%). The stage of bone destruction in HTLV-I carriers with articular symptoms was milder than that in RApatients without HTLV-I. The relative risk of HTLV-I infection for polyarthritis was 1.66 (p < 0.05). CONCLUSION: This is the first epidemiological report clarifying the association between HTLV-I and polyarthritis. Our results suggest that this viral infection has a relationship to RA.
Authors: K Eguchi; N Matsuoka; H Ida; M Nakashima; M Sakai; S Sakito; A Kawakami; K Terada; H Shimada; Y Kawabe Journal: Ann Rheum Dis Date: 1992-06 Impact factor: 19.103
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Authors: Y Iwakura; M Tosu; E Yoshida; M Takiguchi; K Sato; I Kitajima; K Nishioka; K Yamamoto; T Takeda; M Hatanaka Journal: Science Date: 1991-08-30 Impact factor: 47.728
Authors: K Terada; S Katamine; K Eguchi; R Moriuchi; M Kita; H Shimada; I Yamashita; K Iwata; Y Tsuji; S Nagataki Journal: Lancet Date: 1994-10-22 Impact factor: 79.321
Authors: M Mochizuki; T Watanabe; K Yamaguchi; K Takatsuki; K Yoshimura; M Shirao; S Nakashima; S Mori; S Araki; N Miyata Journal: Jpn J Cancer Res Date: 1992-03
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Authors: Sheila N Ferraz; Gabriela F Costa; José Abraão Carneiro Neto; Thiago Hebert; Cassius J V de Oliveira; Mariele Guerra; Lívia M A Oliveira; Edgar M Carvalho Journal: J Neurovirol Date: 2020-05-08 Impact factor: 2.643