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Literature DB >> 8709292

Characterization of tumor cell lines derived from murine gammaherpesvirus-68-infected mice.

Abstract

Cell lines were derived from mice with murine gammaherpesvirus-68 (MHV-68)-associated lymphoproliferative disease. Four were of an ambiguous phenotype and were MHV-68 negative. One, S11, was a B lymphocyte that contained MHV-68 genomes in both linear and episomal forms and released virus. The line was clonable and grew into tumors in nude mice. This is the first naturally occurring MHV-68-positive B-cell line to be generated, and it will be an invaluable tool for the study of MHV-68 latency.

Entities: Disease Species

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Year: 1996 PMID： 8709292 PMCID： PMC190690 DOI： 10.1128/JVI.70.9.6516-6518.1996

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

19 in total

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