Literature DB >> 1469366

Murine gammaherpesvirus 68 establishes a latent infection in mouse B lymphocytes in vivo.

N P Sunil-Chandra1, S Efstathiou, A A Nash.   

Abstract

Murine gammaherpesvirus 68 (MHV-68) is able to persist in spleen cells of infected mice. To determine the cell type harbouring persistent virus, spleen cells from infected animals were separated into immunoglobulin (Ig)-positive (B cell-enriched), Ig-negative (T cell-enriched) and plastic-adherent (macrophage-enriched) fractions. These cells were co-cultivated with permissive BHK-21 cells in an infectious centre assay. The consistent recovery and enrichment of infectious centres in the Ig-positive fraction clearly demonstrates that B cells are a major site of virus persistence/latency. This observation indicates that MHV-68 is biologically similar to Epstein-Barr virus and other members of the B cell lymphotropic gammaherpesvirus 1 subgroup.

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Year:  1992        PMID： 1469366     DOI： 10.1099/0022-1317-73-12-3275

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  193 in total

1.  Turnover of T cells in murine gammaherpesvirus 68-infected mice.

Authors:  A M Hamilton-Easton; J P Christensen; P C Doherty
Journal:  J Virol       Date:  1999-09       Impact factor: 5.103

2.  Identification and initial characterization of the murine gammaherpesvirus 68 gene M3, encoding an abundantly secreted protein.

Authors:  V van Berkel; K Preiter; H W Virgin; S H Speck
Journal:  J Virol       Date:  1999-05       Impact factor: 5.103

3.  Quantitative analysis of the acute and long-term CD4(+) T-cell response to a persistent gammaherpesvirus.

Authors:  J P Christensen; P C Doherty
Journal:  J Virol       Date:  1999-05       Impact factor: 5.103

4.  CD4(+) T cell-mediated control of a gamma-herpesvirus in B cell-deficient mice is mediated by IFN-gamma.

Authors:  J P Christensen; R D Cardin; K C Branum; P C Doherty
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-27       Impact factor: 11.205

5.  Macrophages are the major reservoir of latent murine gammaherpesvirus 68 in peritoneal cells.

Authors:  K E Weck; S S Kim; I V Virgin HW; S H Speck
Journal:  J Virol       Date:  1999-04       Impact factor: 5.103

6.  Murine gammaherpesvirus 68 cyclin D homologue is required for efficient reactivation from latency.

Authors:  A T Hoge; S B Hendrickson; W H Burns
Journal:  J Virol       Date:  2000-08       Impact factor: 5.103

7.  Analysis of virus-specific CD4(+) t cells during long-term gammaherpesvirus infection.

Authors:  E Flaño; D L Woodland; M A Blackman; P C Doherty
Journal:  J Virol       Date:  2001-08       Impact factor: 5.103

8.  Virus reconstituted from infectious bacterial artificial chromosome (BAC)-cloned murine gammaherpesvirus 68 acquires wild-type properties in vivo only after excision of BAC vector sequences.

Authors:  H Adler; M Messerle; U H Koszinowski
Journal:  J Virol       Date:  2001-06       Impact factor: 5.103

9.  Disruption of gammaherpesvirus 68 gene 50 demonstrates that Rta is essential for virus replication.

Authors:  Iglika V Pavlova; Herbert W Virgin; Samuel H Speck
Journal:  J Virol       Date:  2003-05       Impact factor: 5.103

10.  Antibody to a lytic cycle viral protein decreases gammaherpesvirus latency in B-cell-deficient mice.

Authors:  Shivaprakash Gangappa; Sharookh B Kapadia; Samuel H Speck; Herbert W Virgin
Journal:  J Virol       Date:  2002-11       Impact factor: 5.103
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