Literature DB >> 8709279

DNA double-strand break repair functions defend against parvovirus infection.

T J Tauer1, M H Schneiderman, J K Vishwanatha, S L Rhode.   

Abstract

We measured parvovirus replication and sensitivity to X-ray damage in nine CHO cell lines representing a variety of DNA repair deficiencies. We found that parvovirus replication efficiency increases with radiosensitivity. Parvovirus replication is disrupted at an early stage of infection in DNA repair-proficient cells, before conversion of the single-stranded viral DNA genome into the double-stranded replicative form. Thus, status of the DNA repair machinery inversely correlates with parvovirus replication and is proportional to the host's ability to repair X-ray-induced damage.

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Year:  1996        PMID: 8709279      PMCID: PMC190677          DOI: 10.1128/JVI.70.9.6446-6449.1996

Source DB:  PubMed          Journal:  J Virol        ISSN: 0022-538X            Impact factor:   5.103


  23 in total

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