| Literature DB >> 8709279 |
T J Tauer1, M H Schneiderman, J K Vishwanatha, S L Rhode.
Abstract
We measured parvovirus replication and sensitivity to X-ray damage in nine CHO cell lines representing a variety of DNA repair deficiencies. We found that parvovirus replication efficiency increases with radiosensitivity. Parvovirus replication is disrupted at an early stage of infection in DNA repair-proficient cells, before conversion of the single-stranded viral DNA genome into the double-stranded replicative form. Thus, status of the DNA repair machinery inversely correlates with parvovirus replication and is proportional to the host's ability to repair X-ray-induced damage.Entities:
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Year: 1996 PMID: 8709279 PMCID: PMC190677 DOI: 10.1128/JVI.70.9.6446-6449.1996
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103