Literature DB >> 8709278

The human T-cell leukemia virus type 1 posttranscriptional trans-activator Rex contains a nuclear export signal.

D Palmeri1, M H Malim.   

Abstract

The Rex protein of human T-cell leukemia virus type 1 is required for the nuclear export of unspliced viral mRNA and, therefore, for virus replication. In this manuscript, we demonstrate that Rex shuttles between the nucleus and the cytoplasm and that its activation domain constitutes a nuclear export signal that specifies efficient transport to the cytoplasm. These findings are consistent with a model for Rex-mediated trans-activation in which Rex-viral mRNA complexes are targeted for nuclear export by the direct action of the activation domain.

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Year:  1996        PMID： 8709278      PMCID： PMC190676          DOI： 10.1128/JVI.70.9.6442-6445.1996

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  39 in total

1.  Transcriptional (p40x) and post-transcriptional (p27x-III) regulators are required for the expression and replication of human T-cell leukemia virus type I genes.

Authors:  J Inoue; M Yoshida; M Seiki
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205

2.  A second post-transcriptional trans-activator gene required for HTLV-III replication.

Authors:  J Sodroski; W C Goh; C Rosen; A Dayton; E Terwilliger; W Haseltine
Journal:  Nature       Date:  1986 May 22-28       Impact factor: 49.962

3.  rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA.

Authors:  B K Felber; M Hadzopoulou-Cladaras; C Cladaras; T Copeland; G N Pavlakis
Journal:  Proc Natl Acad Sci U S A       Date:  1989-03       Impact factor: 11.205

4.  The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA.

Authors:  M H Malim; J Hauber; S Y Le; J V Maizel; B R Cullen
Journal:  Nature       Date:  1989-03-16       Impact factor: 49.962

5.  HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA.

Authors:  M B Feinberg; R F Jarrett; A Aldovini; R C Gallo; F Wong-Staal
Journal:  Cell       Date:  1986-09-12       Impact factor: 41.582

6.  Sequence requirements for nucleolar localization of human T cell leukemia virus type I pX protein, which regulates viral RNA processing.

Authors:  H Siomi; H Shida; S H Nam; T Nosaka; M Maki; M Hatanaka
Journal:  Cell       Date:  1988-10-21       Impact factor: 41.582

7.  Definition of the human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex protein activation domain by functional exchange.

Authors:  I Weichselbraun; G K Farrington; J R Rusche; E Böhnlein; J Hauber
Journal:  J Virol       Date:  1992-04       Impact factor: 5.103

8.  Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm.

Authors:  S Piñol-Roma; G Dreyfuss
Journal:  Nature       Date:  1992-02-20       Impact factor: 49.962

9.  Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma.

Authors:  B J Poiesz; F W Ruscetti; A F Gazdar; P A Bunn; J D Minna; R C Gallo
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205

10.  Post-transcriptional regulator (rex) of HTLV-1 initiates expression of viral structural proteins but suppresses expression of regulatory proteins.

Authors:  M Hidaka; J Inoue; M Yoshida; M Seiki
Journal:  EMBO J       Date:  1988-02       Impact factor: 11.598
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  36 in total

1.  A novel transferable nuclear export signal mediates CRM1-independent nucleocytoplasmic shuttling of the human cytomegalovirus transactivator protein pUL69.

Authors:  P Lischka; O Rosorius; E Trommer; T Stamminger
Journal:  EMBO J       Date:  2001-12-17       Impact factor: 11.598

2.  CRM1-dependent function of a cis-acting RNA export element.

Authors:  Ileana Popa; Matthew E Harris; John E Donello; Thomas J Hope
Journal:  Mol Cell Biol       Date:  2002-04       Impact factor: 4.272

3.  Identification of novel Saccharomyces cerevisiae proteins with nuclear export activity: cell cycle-regulated transcription factor ace2p shows cell cycle-independent nucleocytoplasmic shuttling.

Authors:  T H Jensen; M Neville; J C Rain; T McCarthy; P Legrain; M Rosbash
Journal:  Mol Cell Biol       Date:  2000-11       Impact factor: 4.272

4.  Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence.

Authors:  M Dobbelstein; J Roth; W T Kimberly; A J Levine; T Shenk
Journal:  EMBO J       Date:  1997-07-16       Impact factor: 11.598

5.  Export of hepatitis B virus RNA on a Rev-like pathway: inhibition by the regenerating liver inhibitory factor IkappaB alpha.

Authors:  J Roth; M Dobbelstein
Journal:  J Virol       Date:  1997-11       Impact factor: 5.103

Review 6.  The human T-cell leukemia virus Rex protein.

Authors:  Ihab Younis; Patrick L Green
Journal:  Front Biosci       Date:  2005-01-01

7.  Tax & rex: overlapping genes of the Deltaretrovirus group.

Authors:  Kathleen Margaret McGirr; Gertrude Case Buehuring
Journal:  Virus Genes       Date:  2006-06       Impact factor: 2.332

8.  Differential requirements for alternative splicing and nuclear export functions of equine infectious anemia virus Rev protein.

Authors:  M E Harris; R R Gontarek; D Derse; T J Hope
Journal:  Mol Cell Biol       Date:  1998-07       Impact factor: 4.272

9.  Importin beta can mediate the nuclear import of an arginine-rich nuclear localization signal in the absence of importin alpha.

Authors:  D Palmeri; M H Malim
Journal:  Mol Cell Biol       Date:  1999-02       Impact factor: 4.272

10.  Phosphorylation regulates human T-cell leukemia virus type 1 Rex function.

Authors:  Matthew Kesic; Rami Doueiri; Michael Ward; O John Semmes; Patrick L Green
Journal:  Retrovirology       Date:  2009-11-17       Impact factor: 4.602
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