Literature DB >> 3035544

Transcriptional (p40x) and post-transcriptional (p27x-III) regulators are required for the expression and replication of human T-cell leukemia virus type I genes.

J Inoue, M Yoshida, M Seiki.   

Abstract

The pX sequence of human T-cell leukemia virus type I codes for three products: p40x, p27x-III, and p21x-III. p40x is a transcriptional trans-activator that activates not only the viral long terminal repeat but also cellular genes for interleukin 2 and its receptor. p27x-III and p21x-III are not required for transcriptional activation, and their functions were unknown. Cotransfection experiments with defective human T-cell leukemia virus type I proviruses and various pX expression plasmids revealed that p27x-III, in addition to p40x, was required for gag gene expression. Furthermore, it was shown that p27x-III induced accumulation of a high level of unspliced viral gag mRNA. These results indicate that p27x-III is a post-transcriptional modulator of viral RNA whose transcription has been fully activated by p40x.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3035544      PMCID： PMC304933          DOI： 10.1073/pnas.84.11.3653

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  37 in total

1.  A second post-transcriptional trans-activator gene required for HTLV-III replication.

Authors:  J Sodroski; W C Goh; C Rosen; A Dayton; E Terwilliger; W Haseltine
Journal:  Nature       Date:  1986 May 22-28       Impact factor: 49.962

2.  Cis-acting sequences responsible for the transcriptional activation of human T-cell leukemia virus type I constitute a conditional enhancer.

Authors:  H Paskalis; B K Felber; G N Pavlakis
Journal:  Proc Natl Acad Sci U S A       Date:  1986-09       Impact factor: 11.205

3.  HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA.

Authors:  M B Feinberg; R F Jarrett; A Aldovini; R C Gallo; F Wong-Staal
Journal:  Cell       Date:  1986-09-12       Impact factor: 41.582

4.  A single species of pX mRNA of human T-cell leukemia virus type I encodes trans-activator p40x and two other phosphoproteins.

Authors:  K Nagashima; M Yoshida; M Seiki
Journal:  J Virol       Date:  1986-11       Impact factor: 5.103

5.  Requirement of multiple copies of a 21-nucleotide sequence in the U3 regions of human T-cell leukemia virus type I and type II long terminal repeats for trans-acting activation of transcription.

Authors:  K Shimotohno; M Takano; T Teruuchi; M Miwa
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

6.  The p40x of human T-cell leukemia virus type I is a trans-acting activator of viral gene transcription.

Authors:  M Seiki; J Inoue; T Takeda; A Hikikoshi; M Sato; M Yoshida
Journal:  Jpn J Cancer Res       Date:  1985-12

7.  Nucleotide sequence of the protease-coding region in an infectious DNA of simian retrovirus (STLV) of the HTLV-I family.

Authors:  J Inoue; T Watanabe; M Sato; A Oda; K Toyoshima; M Yoshida; M Seiki
Journal:  Virology       Date:  1986-04-15       Impact factor: 3.616

8.  Direct evidence that p40x of human T-cell leukemia virus type I is a trans-acting transcriptional activator.

Authors:  M Seiki; J Inoue; T Takeda; M Yoshida
Journal:  EMBO J       Date:  1986-03       Impact factor: 11.598

9.  A transcriptional enhancer sequence of HTLV-I is responsible for trans-activation mediated by p40 chi HTLV-I.

Authors:  J Fujisawa; M Seiki; M Sato; M Yoshida
Journal:  EMBO J       Date:  1986-04       Impact factor: 11.598

10.  Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1.

Authors:  J Inoue; M Seiki; T Taniguchi; S Tsuru; M Yoshida
Journal:  EMBO J       Date:  1986-11       Impact factor: 11.598
View more
  130 in total

1.  Effects of homology length in the repeat region on minus-strand DNA transfer and retroviral replication.

Authors:  Q Dang; W S Hu
Journal:  J Virol       Date:  2001-01       Impact factor: 5.103

2.  R region sequences in the long terminal repeat of a murine retrovirus specifically increase expression of unspliced RNAs.

Authors:  A M Trubetskoy; S A Okenquist; J Lenz
Journal:  J Virol       Date:  1999-04       Impact factor: 5.103

3.  Anti-Rex aptamers as mimics of the Rex-binding element.

Authors:  S Baskerville; M Zapp; A D Ellington
Journal:  J Virol       Date:  1999-06       Impact factor: 5.103

4.  Immortalization of T lymphocytes by human T-cell leukemia virus type 1 is independent of the tax-CBP/p300 interaction.

Authors:  M D Robek; L Ratner
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

Review 5.  Mechanism of action of regulatory proteins encoded by complex retroviruses.

Authors:  B R Cullen
Journal:  Microbiol Rev       Date:  1992-09

6.  Specific binding of the human T-cell leukemia virus type I Rex protein to a short RNA sequence located within the Rex-response element.

Authors:  H P Bogerd; L S Tiley; B R Cullen
Journal:  J Virol       Date:  1992-12       Impact factor: 5.103

7.  Protein isoforms encoded by the pX region of human T-cell leukemia/lymphotropic virus type I.

Authors:  I J Koralnik; A Gessain; M E Klotman; A Lo Monico; Z N Berneman; G Franchini
Journal:  Proc Natl Acad Sci U S A       Date:  1992-09-15       Impact factor: 11.205

8.  The indirect association of human T-cell leukemia virus tax protein with DNA results in transcriptional activation.

Authors:  J Fujisawa; M Toita; T Yoshimura; M Yoshida
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

9.  Effects of a highly basic region of human immunodeficiency virus Tat protein on nucleolar localization.

Authors:  H Siomi; H Shida; M Maki; M Hatanaka
Journal:  J Virol       Date:  1990-04       Impact factor: 5.103

10.  Nucleolar localization of myc transcripts.

Authors:  V C Bond; B Wold
Journal:  Mol Cell Biol       Date:  1993-06       Impact factor: 4.272
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.