| Literature DB >> 8709118 |
M Gordaliza1, G T Faircloth, M A Castro, J M Miguel del Corral, M L López-Vázquez, A San Feliciano.
Abstract
The immunosuppressive activity of several lactonic, nonlactonic, and heterocycle-fused cyclolignans has been demonstrated for the first time by use of a T-cell-mediated immune response. Of the compounds tested, 4'-demethyldeoxypodophyllotoxin (8), beta-apopicropodophyllin (6), and the isoxazoline-fused cyclolignan 15 are the most potent with respect to their suppression of activated splenocytes.Entities:
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Year: 1996 PMID： 8709118 DOI： 10.1021/jm960023h
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446