Literature DB >> 8709116

Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents.

A Gueiffier1, M Lhassani, A Elhakmaoui, R Snoeck, G Andrei, O Chavignon, J C Teulade, A Kerbal, E M Essassi, J C Debouzy, M Witvrouw, Y Blache, J Balzarini, E De Clercq, J P Chapat.   

Abstract

The synthesis and the antiviral activities of C-3 acyclic nucleoside analogues of imidazo[1,2-a]pyridine and pyrimidine are reported. From these compounds, 20, 21, 22, 23, 28, and 34 showed a specific activity against cytomegalovirus and/or varicella-zoster virus.

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Year:  1996        PMID： 8709116     DOI： 10.1021/jm9507901

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  10 in total

1.  2-Amino-pyrimidinium picrate.

Authors:  B Narayana; B K Sarojini; K Prakash Kamath; H S Yathirajan; Michael Bolte
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2007-12-06

2.  Gold Catalysed Redox Synthesis of Imidazo[1,2-a]pyridine using Pyridine N-Oxide and Alkynes.

Authors:  Eric P A Talbot; Melodie Richardson; Jeffrey M McKenna; F Dean Toste
Journal:  Adv Synth Catal       Date:  2014-03-10       Impact factor: 5.837

3.  The Dimroth Rearrangement in the Synthesis of Condensed Pyrimidines - Structural Analogs of Antiviral Compounds.

Authors:  Vakhid А Mamedov; Nataliya А Zhukova; Milyausha S Kadyrova
Journal:  Chem Heterocycl Compd (N Y)       Date:  2021-05-15       Impact factor: 1.277

4.  2-Amino-pyrimidinium dihydrogen phosphate monohydrate.

Authors:  Houda Marouani; Salem S Al-Deyab; Mohamed Rzaigui
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-03-26

5.  Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells.

Authors:  Lisa Yu; Andres Lopez; Abderrahmane Anaflous; Brahim El Bali; Abdellah Hamal; Elke Ericson; Lawrence E Heisler; Angus McQuibban; Guri Giaever; Corey Nislow; Charles Boone; Grant W Brown; Mohammed Bellaoui
Journal:  PLoS Genet       Date:  2008-11-28       Impact factor: 5.917

6.  The pseudo-Michael reaction of 1-aryl-4,5-dihydro-1H-imidazol-2-amines with ethyl ethoxymethylenecyanoacetate.

Authors:  Agnieszka A Kaczor; Urszula Kijkowska-Murak; Kalevi Pihlaja; Jari Sinkkonen; Waldemar Wysocki; Zbigniew Karczmarzyk; Dariusz Matosiuk
Journal:  Monatsh Chem       Date:  2013-05-14       Impact factor: 1.451

7.  Synthesis, central nervous system activity, and structure-activity relationship of 1-aryl-6-benzyl-7-hydroxy-2,3-dihydroimidazo[1,2-a]pyrimidine-5(1H)-ones.

Authors:  Marzena Rządkowska; Elżbieta Szacoń; Agnieszka A Kaczor; Sylwia Fidecka; Ewa Kędzierska; Dariusz Matosiuk
Journal:  Med Chem Res       Date:  2014-03-27       Impact factor: 1.965

8.  Synthesis, Molecular Docking, and Antimycotic Evaluation of Some 3-Acyl Imidazo[1,2-a]pyrimidines.

Authors:  Omar Gómez-García; Dulce Andrade-Pavón; Elena Campos-Aldrete; Ricardo Ballinas-Indilí; Alfonso Méndez-Tenorio; Lourdes Villa-Tanaca; Cecilio Álvarez-Toledano
Journal:  Molecules       Date:  2018-03-07       Impact factor: 4.411

9.  Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof.

Authors:  Mikhail S Novikov; Denis A Babkov; Maria P Paramonova; Anastasia L Khandazhinskaya; Alexander A Ozerov; Alexander O Chizhov; Graciela Andrei; Robert Snoeck; Jan Balzarini; Katherine L Seley-Radtke
Journal:  Bioorg Med Chem       Date:  2013-05-16       Impact factor: 3.641

10.  Microwave assisted synthesis of bis and tris(ω-bromoacetophenones): versatile precursors for novel bis(imidazo[1,2-a]pyridines), bis(imidazo[1,2-a]pyrimidines) and their tris-analogs.

Authors:  Mohamed R Shaaban
Journal:  Chem Cent J       Date:  2013-06-19       Impact factor: 4.215
  10 in total

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