Literature DB >> 870835

The effect of clonidine on gastric acid secretion in rats and dogs.

H M Jennewein.   

Abstract

The effect of clonidine on gastric acid secretion was investigated using rats and dogs. In the stomach lumen perfused rat basal gastric acid secretion was increased by clonidine in the anaesthetized rat but inhibited in the conscious animal. Clonidine also reduced the basal gastric acid secretion in rats with chronic gastric fistula, (ED50 12 microng/kg p.O.). In addition, gastric secretion stimulated by insulin hypoglycaemia was inhibited by clonidine in anaesthetized stomach lumen perfused rats and in conscious dogs with gastric fistula. In the rat gastric secretion stimulated by electrical vagus stimulation was inhibited as well. However, clonidine had no effect on the gastric acid secretion stimulated by carbachol in stomach lumen perfused rats and in dogs with denervated fundic pouch. These results suggest that the inhibition of gastric acid secretion by clonidine probably is due to an inhibition of acetylcholine release at the vagus nerve endings. Additional central gastric antisecretory effects can, however, not be excluded by this study.

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Year:  1977        PMID： 870835     DOI： 10.1007/bf00508814

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  18 in total

Review 1.  Drug therapy: clonidine, a new antihypertensive drug.

Authors:  W A Pettinger
Journal:  N Engl J Med       Date:  1975-12-04       Impact factor: 91.245

2.  MECHANISM OF ACTION OF RESERPINE AND INSULIN ON GASTRIC AMINES AND GASTRIC ACID SECRETION, AND THE EFFECT OF MONOAMINE OXIDASE INHIBITION.

Authors:  K S KIM; P A SHORE
Journal:  J Pharmacol Exp Ther       Date:  1963-09       Impact factor: 4.030

3.  Effect of restraint on gastric acidity in the rat.

Authors:  D A BRODIE; R W MARSHALL; O M MORENO
Journal:  Am J Physiol       Date:  1962-04

4.  Action of insulin hypoglycemia on motor and secretory functions of the digestive tract.

Authors:  W H BACHRACH
Journal:  Physiol Rev       Date:  1953-10       Impact factor: 37.312

5.  Increased production of cyclic AMP in gastric tissue by stimulation of histamine2 (H2)-receptors.

Authors:  H O Karppanen; E Westermann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000

6.  Actions of clonidine and 2-(2-methyl-6-ethyl-cyclohexylamino)-2-oxazoline on postganglionic autonomic nerves.

Authors:  U Werner; K Starke; H J Schümann
Journal:  Arch Int Pharmacodyn Ther       Date:  1972-02

7.  Pharmacological inhibition of adrenaline secretion following insulin induced hypoglycaemia in man: the effect of Catapresan.

Authors:  H Hedeland; J F Dymling; B Hökfelt
Journal:  Acta Endocrinol (Copenh)       Date:  1971-05

8.  The influence of 2-(2,6-dichlorphenylamino)-2-imidazoline hydrochloride (clonidine) and some related compounds on gastric secretion in the anaesthetized rat.

Authors:  A Walz; P A van Zwieten
Journal:  Eur J Pharmacol       Date:  1970       Impact factor: 4.432

9.  Localization of the hypotenisve effect of 2-(2-6-dichlorophenylamino)-2-imidazoline hydrochloride (St 155, Catapresan).

Authors:  H Schmitt; H Schmitt
Journal:  Eur J Pharmacol       Date:  1969-04       Impact factor: 4.432

10.  STUDIES ON GASTRIN.

Authors:  S K LAI
Journal:  Gut       Date:  1964-08       Impact factor: 23.059
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  5 in total

1.  Stimulation of central alpha-2 adrenoceptors inhibits gastric secretion in rats by releasing vasopressin.

Authors:  J Puurunen
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-02       Impact factor: 3.000

2.  Studies on the effect of clonidine on histamine h2-receptors in the uterus, heart and gastric mucosa [proceedings].

Authors:  M E Parsons
Journal:  Agents Actions       Date:  1978-06

3.  Influence of dopamine receptor agonists on gastric acid secretion induced by intraventricular administration of thyrotropin-releasing hormone in the perfused stomach of anaesthetized rats.

Authors:  M Maeda-Hagiwara; K Watanabe
Journal:  Br J Pharmacol       Date:  1983-05       Impact factor: 8.739

4.  Evidence for two opposite effects of clonidine on gastric acid secretion in the dog.

Authors:  G Soldani; M Del Tacca; C Bernardini; E Martinotti; M Impicciatore
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-09       Impact factor: 3.000

5.  The effect of alpha 2-adrenoceptor agonists on the acid secretory responses of rat isolated gastric mucosa to electrical field stimulation.

Authors:  P W Dettmar; J A Lord
Journal:  Br J Pharmacol       Date:  1986-10       Impact factor: 8.739
  5 in total

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