Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Elevated sister chromatid exchange rate in lymphocytes of subjects treated with arsenic.

Literature DB >> 870411

Elevated sister chromatid exchange rate in lymphocytes of subjects treated with arsenic.

Abstract

An elevated sister chromatid exchange (SCE) rate was found in the lymphocytes of six patients treated with arsenic. All had stigmata of arsenic use as well as biopsy-proven skin cancers. The arsenic exposed patients had a mean of 14.00 SCE/mitosis while 44 normal controls had a mean of 5.8 SCE/mitosis. Chromosome breakage analysis revealed no difference between the two groups. SCE rate has been shown to be elevated in a variety of systems where cell cultures or experimental animals were exposed to known mutagens and carcinogens. We suggest that the relationship carcinogen exposure-elevated SCE rate-cancer may also be valid in humans treated with arsenic.

Entities: Chemical Disease Species

Mesh：

Substances：
Mutagens
Arsenic

Year: 1977 PMID： 870411 DOI： 10.1007/bf00390438

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

12 in total

1. Analysis of sister chromatid exchange formation in vivo in mouse spermatogonia as a new test system for environmental mutagens.

Authors: J W Allen; S A Latt
Journal: Nature Date: 1976-04-01 Impact factor: 49.962

2. Differential chromatid staining by in vivo treatment as a mutagenicity test system.

Authors: W Vogel; T Bauknecht
Journal: Nature Date: 1976-04-01 Impact factor: 49.962

3. Skin cancer in chronic arsenicism.

Authors: S Yeh
Journal: Hum Pathol Date: 1973-12 Impact factor: 3.466

4. Induction of chromosome breaks in cultured normal human leukocytes by potassium arsenite, hydroxyurea and related compounds.

Authors: J J Oppenheim; W N Fishbein
Journal: Cancer Res Date: 1965-08 Impact factor: 12.701

5. Giemsa technique for the detection of sister chromatid exchanges.

Authors: J R Korenberg; E F Freedlender
Journal: Chromosoma Date: 1974 Impact factor: 4.316

6. A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes.

Authors: R S Chaganti; S Schonberg; J German
Journal: Proc Natl Acad Sci U S A Date: 1974-11 Impact factor: 11.205

7. Sister chromatid exchange in xeroderma pigmentosum cells that are defective in DNA excision repair or post-replication repair.

Authors: S Wolff; J Bodycote; G H Thomas; J E Cleaver
Journal: Genetics Date: 1975-10 Impact factor: 4.562

8. Chromosome studies on lymphocytes of patients under cytostatic therapy. II. Studies Using the BUDR-labelling technique in cytostatic interval therapy.

Authors: E Gebhart; B Windolph; F Wopfner
Journal: Hum Genet Date: 1980 Impact factor: 4.132

Review 9. Arsenic: opportunity for risk assessment.

Authors: G Stöhrer
Journal: Arch Toxicol Date: 1991 Impact factor: 5.153

10. Sister chromatid exchanges in human peripheral blood lymphocytes after ingestion of high doses of arsenicals.

Authors: P Hantson; C Verellen-Dumoulin; J M Libouton; A Leonard; E D Leonard; P Mahieu
Journal: Int Arch Occup Environ Health Date: 1996 Impact factor: 3.015

Elevated sister chromatid exchange rate in lymphocytes of subjects treated with arsenic.

1. Analysis of sister chromatid exchange formation in vivo in mouse spermatogonia as a new test system for environmental mutagens.

2. Differential chromatid staining by in vivo treatment as a mutagenicity test system.

3. Skin cancer in chronic arsenicism.

4. Induction of chromosome breaks in cultured normal human leukocytes by potassium arsenite, hydroxyurea and related compounds.

5. Giemsa technique for the detection of sister chromatid exchanges.

6. A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes.

7. Sister chromatid exchange in xeroderma pigmentosum cells that are defective in DNA excision repair or post-replication repair.

8. Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange.

9. Sister chromatid exchange in dyskeratosis congenita lymphocytes.

10. Sister chromatid exchange in human chromosomes from normal individuals and patients with ataxia telangiectasia.

1. Inorganic arsenic compounds: are they carcinogenic, mutagenic, teratogenic?

2. Sister chromatid exchange in lymphocytes from patients with acute lymphoblastic leukemia.

3. Chromosome aberrations in psoriatic patients treated with arsenic.

4. Normal sister chromatid exchange in lymphocytes from patients with multiple epidermal cancer?

5. Sister chromatid exchange in lymphocytes from patients with malignant lymphoma.

Review 6. Sister chromatid exchange (SCE) and structural chromosome aberration in mutagenicity testing.

7. Investigation of the sister chromatid exchange (SCE) frequency in one patient with xeroderma pigmentosum.

8. Chromosome studies on lymphocytes of patients under cytostatic therapy. II. Studies Using the BUDR-labelling technique in cytostatic interval therapy.

Review 9. Arsenic: opportunity for risk assessment.

10. Sister chromatid exchanges in human peripheral blood lymphocytes after ingestion of high doses of arsenicals.