Literature DB >> 8704

Studies on selenium-related compounds. V. Cytogenetic effect and reactivity with DNA.

K Nakamuro, K Yoshikawa, Y Sayato, H Kurata, M Tonomura.   

Abstract

Five selenium compounds, Na2Se04, H2Se04, Na2Se03, H2Se03 and Se02, were tested for their capacity to induce chromosome aberrations in cultured human leukocytes and for their reactivity with DNA by a rec-assay system and inactivation of transforming activity in Bacillus subtilis. Chromosome-breaking activity was significantly higher for the compounds with four-valent than with six-valent selenium, the efficiency being in the decreasing order H2S03 greater than Na2Se03 greater than Se02 greater than H2Se04 greater than Na2Se04. Rec assay using B. subtilis with different recombination capacities suggested that damage to DNA was produced by selenites but not by selenates. The reactivity of selenites with DNA was also indicated by a significant loss of transformation of the tryptophan marker of B. subtilis DNA treated with H2Se03 and Se02.

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Year:  1976        PMID： 8704     DOI： 10.1016/0165-1218(76)90042-2

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  8 in total

1.  Evidence for the antimutagenicity and the mutagenicity of selenium.

Authors:  R J Shamberger
Journal:  Biol Trace Elem Res       Date:  1980-03       Impact factor: 3.738

2.  Investigating the Generalizability of the MultiFlow ® DNA Damage Assay and Several Companion Machine Learning Models With a Set of 103 Diverse Test Chemicals.

Authors:  Steven M Bryce; Derek T Bernacki; Stephanie L Smith-Roe; Kristine L Witt; Jeffrey C Bemis; Stephen D Dertinger
Journal:  Toxicol Sci       Date:  2018-03-01       Impact factor: 4.849

3.  The antimutagenic effect of selenium on 7,12-dimethylbenz(a)anthracene and metabolites in the amesSalmonella/microsome system.

Authors:  L K Arciszewska; S E Martin; J A Milner
Journal:  Biol Trace Elem Res       Date:  1982-12       Impact factor: 3.738

Review 4.  Effects of metals in in vitro bioassays.

Authors:  M A Sirover
Journal:  Environ Health Perspect       Date:  1981-08       Impact factor: 9.031

Review 5.  The role of metals in carcinogenesis: biochemistry and metabolism.

Authors:  K W Jennette
Journal:  Environ Health Perspect       Date:  1981-08       Impact factor: 9.031

Review 6.  Metallic elements in fossil fuel combustion products: amounts and form of emissions and evaluation of carcinogenicity and mutagenicity.

Authors:  V B Vouk; W T Piver
Journal:  Environ Health Perspect       Date:  1983-01       Impact factor: 9.031

Review 7.  Metal interactions in carcinogenesis: enhancement, inhibition.

Authors:  G F Nordberg; O Andersen
Journal:  Environ Health Perspect       Date:  1981-08       Impact factor: 9.031

Review 8.  Role of cobalt, iron, lead, manganese, mercury, platinum, selenium, and titanium in carcinogenesis.

Authors:  G Kazantzis
Journal:  Environ Health Perspect       Date:  1981-08       Impact factor: 9.031
  8 in total

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