Literature DB >> 8700895

Expression of protein encoded by varicella-zoster virus open reading frame 63 in latently infected human ganglionic neurons.

R Mahalingam1, M Wellish, R Cohrs, S Debrus, J Piette, B Rentier, D H Gilden.   

Abstract

The ganglionic cell type in which varicella-zoster virus (VZV) is latent in humans was analyzed by using antibodies raised against in vitro-expressed VZV open reading frame 63 protein. VZV open reading frame 63 protein was detected exclusively in the cytoplasm of neurons of latently infected human trigeminal and thoracic ganglia. This is, to our knowledge, the first identification of a herpesvirus protein expressed during latency in the human nervous system.

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Year:  1996        PMID： 8700895      PMCID： PMC39920          DOI： 10.1073/pnas.93.5.2122

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  19 in total

1.  Persistence of varicella-zoster virus DNA in elderly patients with postherpetic neuralgia.

Authors:  R Mahalingam; M Wellish; J Brucklier; D H Gilden
Journal:  J Neurovirol       Date:  1995-03       Impact factor: 2.643

2.  Latent varicella-zoster viral DNA in human trigeminal and thoracic ganglia.

Authors:  R Mahalingam; M Wellish; W Wolf; A N Dueland; R Cohrs; A Vafai; D Gilden
Journal:  N Engl J Med       Date:  1990-09-06       Impact factor: 91.245

3.  Varicella-zoster virus (VZV) transcription during latency in human ganglia: construction of a cDNA library from latently infected human trigeminal ganglia and detection of a VZV transcript.

Authors:  R J Cohrs; K Srock; M B Barbour; G Owens; R Mahalingam; M E Devlin; M Wellish; D H Gilden
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

4.  Varicella-zoster virus gene 63 encodes an immediate-early protein that is abundantly expressed during latency.

Authors:  S Debrus; C Sadzot-Delvaux; A F Nikkels; J Piette; B Rentier
Journal:  J Virol       Date:  1995-05       Impact factor: 5.103

Review 5.  Zoster sine herpete, a clinical variant.

Authors:  D H Gilden; R R Wright; S A Schneck; J M Gwaltney; R Mahalingam
Journal:  Ann Neurol       Date:  1994-05       Impact factor: 10.422

6.  PCR-based analysis of herpes simplex virus type 1 latency in the rat trigeminal ganglion established with a ribonucleotide reductase-deficient mutant.

Authors:  R Ramakrishnan; M Levine; D J Fink
Journal:  J Virol       Date:  1994-11       Impact factor: 5.103

7.  Quantitation of latent varicella-zoster virus DNA in human trigeminal ganglia by polymerase chain reaction.

Authors:  R Mahalingam; M Wellish; D Lederer; B Forghani; R Cohrs; D Gilden
Journal:  J Virol       Date:  1993-04       Impact factor: 5.103

8.  Preherpetic neuralgia.

Authors:  D H Gilden; A N Dueland; R Cohrs; J R Martin; B K Kleinschmidt-DeMasters; R Mahalingam
Journal:  Neurology       Date:  1991-08       Impact factor: 9.910

9.  Varicella-zoster virus (VZV) transcription during latency in human ganglia: prevalence of VZV gene 21 transcripts in latently infected human ganglia.

Authors:  R J Cohrs; M B Barbour; R Mahalingam; M Wellish; D H Gilden
Journal:  J Virol       Date:  1995-04       Impact factor: 5.103

10.  Configuration of latent varicella-zoster virus DNA.

Authors:  P Clarke; T Beer; R Cohrs; D H Gilden
Journal:  J Virol       Date:  1995-12       Impact factor: 5.103
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  89 in total

1.  Varicella-zoster virus gene expression in latently infected and explanted human ganglia.

Authors:  P G Kennedy; E Grinfeld; J E Bell
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

2.  Neutralizing anti-gH antibody of Varicella-zoster virus modulates distribution of gH and induces gene regulation, mimicking latency.

Authors:  Kimiyasu Shiraki; Tohru Daikoku; Masaya Takemoto; Yoshihiro Yoshida; Kazuhiro Suzuki; Yasushi Akahori; Toshiomi Okuno; Yoshikazu Kurosawa; Yoshizo Asano
Journal:  J Virol       Date:  2011-06-01       Impact factor: 5.103

3.  Analysis of individual human trigeminal ganglia for latent herpes simplex virus type 1 and varicella-zoster virus nucleic acids using real-time PCR.

Authors:  R J Cohrs; J Randall; J Smith; D H Gilden; C Dabrowski; H van Der Keyl; R Tal-Singer
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

4.  Effect of time delay after necropsy on analysis of simian varicella-zoster virus expression in latently infected ganglia of rhesus macaques.

Authors:  Ravi Mahalingam; Vicki Traina-Dorge; Mary Wellish; Eileen Deharo; Anjani Golive; Ilhem Messaoudi; Don Gilden
Journal:  J Virol       Date:  2010-09-22       Impact factor: 5.103

5.  Varicella-zoster virus ORF63 inhibits apoptosis of primary human neurons.

Authors:  Chantelle Hood; Anthony L Cunningham; Barry Slobedman; Ann M Arvin; Marvin H Sommer; Paul R Kinchington; Allison Abendroth
Journal:  J Virol       Date:  2006-01       Impact factor: 5.103

6.  Naturally acquired simian varicella virus infection in African green monkeys.

Authors:  Ravi Mahalingam; Vicki Traina-Dorge; Mary Wellish; John Smith; Donald H Gilden
Journal:  J Virol       Date:  2002-09       Impact factor: 5.103

7.  Varicella-zoster virus ORF47 protein kinase, which is required for replication in human T cells, and ORF66 protein kinase, which is expressed during latency, are dispensable for establishment of latency.

Authors:  Hitoshi Sato; Lesley Pesnicak; Jeffrey I Cohen
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103

8.  Disseminated simian varicella virus infection in an irradiated rhesus macaque (Macaca mulatta).

Authors:  Krishnan Kolappaswamy; Ravi Mahalingam; Vicki Traina-Dorge; Steven T Shipley; Donald H Gilden; Bette K Kleinschmidt-Demasters; Charles G McLeod; Laura L Hungerford; Louis J DeTolla
Journal:  J Virol       Date:  2006-11-01       Impact factor: 5.103

9.  Nuclear import of the varicella-zoster virus latency-associated protein ORF63 in primary neurons requires expression of the lytic protein ORF61 and occurs in a proteasome-dependent manner.

Authors:  Matthew S Walters; Christos A Kyratsous; Shilin Wan; Saul Silverstein
Journal:  J Virol       Date:  2008-06-18       Impact factor: 5.103

10.  Identification of phosphorylated residues on varicella-zoster virus immediate-early protein ORF63.

Authors:  Niklaus H Mueller; Matthew S Walters; Roland A Marcus; Laurie L Graf; Jessica Prenni; Don Gilden; Saul J Silverstein; Randall J Cohrs
Journal:  J Gen Virol       Date:  2010-01-20       Impact factor: 3.891
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