Literature DB >> 869932

The role of the imidazolyl nitrogen atoms of histidine-12 in ribonuclease S.

O D van Batenburg, I Voskuyl-Holtkamp, C Schattenkerk, K Hoes, K E Kerling, E Havinga.   

Abstract

S-peptide (residues 1--14) analogues in which the active histidine-12 residue is replaced by Npi-methyl-L-histidine, Ntau-methyl-L-histidine and beta-(pyrid-3-yl)-L-alanine were synthesized and tested for their capacity to bind to S-protein and to activate it. The results show that both imidazolyl nitrogen atoms are required for optimal catalytic functioning, Ntau being essential to the catalytic reaction itself, Npi playing a role in keeping the imidazole ring in the correct position.

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Year:  1977        PMID： 869932      PMCID： PMC1164708          DOI： 10.1042/bj1630385

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  11 in total

1.  The active site and mechanism of action of bovine pancreatic ribonuclease. 7. The catalytic mechanism.

Authors:  D Findlay; D G Herries; A P Mathias; B R Rabin; C A Ross
Journal:  Biochem J       Date:  1962-10       Impact factor: 3.857

2.  Assignment of the histidine 12-threonine 45 hydrogen-bonded proton in the NMR spectrum of ribonuclease A in H2O.

Authors:  D J Patel; L L Canuel; C Woodward; F A Bovey
Journal:  Biopolymers       Date:  1975-05       Impact factor: 2.505

3.  Studies on polypeptides.

Authors:  I Voskuyl-Holtkamp; C Schattenkerk; E Havinga
Journal:  Int J Pept Protein Res       Date:  1976

4.  Synthesis, purification, and properties of a semisynthetic ribonuclease S incorporating 4-fluoro-L-histidine at position 12.

Authors:  B M Dunn; C DiBello; K L Kirk; L A Cohen; I M Chaiken
Journal:  J Biol Chem       Date:  1974-10-10       Impact factor: 5.157

Review 5.  Solid-phase peptide synthesis.

Authors:  R B Merrifield
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1969

6.  Spectrophotometric determination of the dissociation constant of ribonuclease S'.

Authors:  B M Woodfin; V Massey
Journal:  J Biol Chem       Date:  1968-03-10       Impact factor: 5.157

7.  An improved synthesis of tert-butyloxycarbonyl-L-histidine.

Authors:  O D van Batenburg; K E Kerling
Journal:  Int J Pept Protein Res       Date:  1976

8.  Geometry of the first step in the action of ribonuclease-A (in-line geometry-uridine2',3'-cyclic thiophosphate- 31 P NMR).

Authors:  D A Usher; E S Erenrich; F Eckstein
Journal:  Proc Natl Acad Sci U S A       Date:  1972-01       Impact factor: 11.205

9.  Synthesis and enzymatic activity of an RNase S' analogue in which the 4-imidazolylglycyl residue takes the position and the role of histidine-12.

Authors:  O D Van Batenburg; K E Kerling; E Havinga
Journal:  FEBS Lett       Date:  1976-10-01       Impact factor: 4.124

10.  The mechanism of action of ribonuclease.

Authors:  G C Roberts; E A Dennis; D H Meadows; J S Cohen; O Jardetzky
Journal:  Proc Natl Acad Sci U S A       Date:  1969-04       Impact factor: 11.205
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  1 in total

1.  Semisynthesis and characterization of mammalian thioredoxin reductase.

Authors:  Brian Eckenroth; Katharine Harris; Anton A Turanov; Vadim N Gladyshev; Ronald T Raines; Robert J Hondal
Journal:  Biochemistry       Date:  2006-04-25       Impact factor: 3.162
  1 in total

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