Literature DB >> 8698527

Entry of Borrelia burgdorferi into macrophages is end-on and leads to degradation in lysosomes.

R R Montgomery1, S E Malawista.   

Abstract

The Lyme disease spirochete, Borrelia burgdorferi, is ingested rapidly by mouse macrophages in vitro. Spirochetes attach by their ends and become progressively coiled as they move deeper into cells. From the earliest measurements, spirochetes colocalize with a marker of endosomes and lysosomes, and degradation of spirochetes occurs within lysosomes.

Entities:  

Mesh：

Year:  1996        PMID： 8698527      PMCID： PMC174158          DOI： 10.1128/iai.64.7.2867-2872.1996

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  35 in total

1.  Protection of mice against the Lyme disease agent by immunizing with recombinant OspA.

Authors:  E Fikrig; S W Barthold; F S Kantor; R A Flavell
Journal:  Science       Date:  1990-10-26       Impact factor: 47.728

Review 2.  Strategies of obligate intracellular parasites for evading host defences.

Authors:  B F Hall; K A Joiner
Journal:  Immunol Today       Date:  1991-03

3.  Clustering of fibronectin adhesins toward Treponema denticola tips upon contact with immobilized fibronectin.

Authors:  J R Dawson; R P Ellen
Journal:  Infect Immun       Date:  1994-06       Impact factor: 3.441

4.  Attachment of virulent Treponema pallidum to human mononuclear phagocytes.

Authors:  B D Brause; R B Roberts
Journal:  Br J Vener Dis       Date:  1978-08

5.  Isolation and characterization of fibronectin-binding sites of Borrelia garinii N34.

Authors:  P A Kopp; M Schmitt; H J Wellensiek; H Blobel
Journal:  Infect Immun       Date:  1995-10       Impact factor: 3.441

6.  Borrelia burgdorferi and the macrophage: routine annihilation but occasional haven?

Authors:  R R Montgomery; S E Malawista
Journal:  Parasitol Today       Date:  1994-04

7.  Phagocytosis of the Legionnaires' disease bacterium (Legionella pneumophila) occurs by a novel mechanism: engulfment within a pseudopod coil.

Authors:  M A Horwitz
Journal:  Cell       Date:  1984-01       Impact factor: 41.582

8.  Interaction of Lyme disease spirochetes with cultured eucaryotic cells.

Authors:  D D Thomas; L E Comstock
Journal:  Infect Immun       Date:  1989-04       Impact factor: 3.441

9.  The fate of Borrelia burgdorferi, the agent for Lyme disease, in mouse macrophages. Destruction, survival, recovery.

Authors:  R R Montgomery; M H Nathanson; S E Malawista
Journal:  J Immunol       Date:  1993-02-01       Impact factor: 5.422

10.  Borrelia burgdorferi binds plasminogen, resulting in enhanced penetration of endothelial monolayers.

Authors:  J L Coleman; T J Sellati; J E Testa; R R Kew; M B Furie; J L Benach
Journal:  Infect Immun       Date:  1995-07       Impact factor: 3.441
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  25 in total

1.  Borrelia burgdorferi organisms lacking plasmids 25 and 28-1 are internalized by human blood phagocytes at a rate identical to that of the wild-type strain.

Authors:  Samiya Al-Robaiy; Jens Knauer; Reinhard K Straubinger
Journal:  Infect Immun       Date:  2005-09       Impact factor: 3.441

2.  Phagocytosis of Borrelia burgdorferi and Treponema pallidum potentiates innate immune activation and induces gamma interferon production.

Authors:  Meagan W Moore; Adriana R Cruz; Carson J LaVake; Amanda L Marzo; Christian H Eggers; Juan C Salazar; Justin D Radolf
Journal:  Infect Immun       Date:  2007-01-12       Impact factor: 3.441

Review 3.  Lyme arthritis: current concepts and a change in paradigm.

Authors:  Dean T Nardelli; Steven M Callister; Ronald F Schell
Journal:  Clin Vaccine Immunol       Date:  2007-11-14

4.  Interleukin-10 alters effector functions of multiple genes induced by Borrelia burgdorferi in macrophages to regulate Lyme disease inflammation.

Authors:  Aarti Gautam; Saurabh Dixit; Mario T Philipp; Shree R Singh; Lisa A Morici; Deepak Kaushal; Vida A Dennis
Journal:  Infect Immun       Date:  2011-09-26       Impact factor: 3.441

5.  Invasion of eukaryotic cells by Borrelia burgdorferi requires β(1) integrins and Src kinase activity.

Authors:  Jing Wu; Eric H Weening; Jennifer B Faske; Magnus Höök; Jon T Skare
Journal:  Infect Immun       Date:  2010-12-20       Impact factor: 3.441

6.  Dual role of MyD88 in rapid clearance of relapsing fever Borrelia spp.

Authors:  Devin D Bolz; Rhianna S Sundsbak; Ying Ma; Shizuo Akira; John H Weis; Tom G Schwan; Janis J Weis
Journal:  Infect Immun       Date:  2006-10-09       Impact factor: 3.441

7.  Borrelia burgdorferi stimulates macrophages to secrete higher levels of cytokines and chemokines than Borrelia afzelii or Borrelia garinii.

Authors:  Klemen Strle; Elise E Drouin; Shiqian Shen; Joseph El Khoury; Gail McHugh; Eva Ruzic-Sabljic; Franc Strle; Allen C Steere
Journal:  J Infect Dis       Date:  2009-12-15       Impact factor: 5.226

8.  Anti-interleukin-15 prevents arthritis in Borrelia-vaccinated and -infected mice.

Authors:  Corey A Amlong; Dean T Nardelli; Sara Heil Peterson; Thomas F Warner; Steven M Callister; Ronald F Schell
Journal:  Clin Vaccine Immunol       Date:  2006-02

9.  Distinct roles for MyD88 and Toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction.

Authors:  Ok S Shin; Ralph R Isberg; Shizuo Akira; Satoshi Uematsu; Aruna K Behera; Linden T Hu
Journal:  Infect Immun       Date:  2008-03-31       Impact factor: 3.441

10.  Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta.

Authors:  Juan C Salazar; Star Duhnam-Ems; Carson La Vake; Adriana R Cruz; Meagan W Moore; Melissa J Caimano; Leonor Velez-Climent; Jonathan Shupe; Winfried Krueger; Justin D Radolf
Journal:  PLoS Pathog       Date:  2009-05-22       Impact factor: 6.823
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