Literature DB >> 8698090

Inhibition of aldose reductase by dihydroflavonols in Engelhardtia chrysolepis and effects on other enzymes.

H Haraguchi1, I Ohmi, H Masuda, Y Tamura, K Mizutani, O Tanaka, W H Chou.   

Abstract

Astilbin and neoastilbin, dihydroflavonol rhamnosides from Engelhardtia chrysolepis, showed potent inhibition of lens aldose reductase. Kinetic analysis showed astilbin exhibited uncompetitive inhibition against both dl-glyceraldehyde and NADPH. These taxifolin glycosides were selective inhibitors of aldose reductase with no inhibition of NADH oxidase.

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Year:  1996        PMID： 8698090     DOI： 10.1007/bf01969729

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  22 in total

1.  Flavonoids as inhibitors of lens aldose reductase.

Authors:  S D Varma; I Mikuni; J H Kinoshita
Journal:  Science       Date:  1975-06-20       Impact factor: 47.728

2.  Inhibition of hexonate dehydrogenase and aldose reductase from bovine retina by sorbinil, statil, M79175 and valproate.

Authors:  R Poulsom
Journal:  Biochem Pharmacol       Date:  1986-09-01       Impact factor: 5.858

3.  Inhibition of aldehyde reductase by aldose reductase inhibitors.

Authors:  S Sato; P F Kador
Journal:  Biochem Pharmacol       Date:  1990-09-01       Impact factor: 5.858

Review 4.  Mechanisms initiating cataract formation. Proctor Lecture.

Authors:  J H Kinoshita
Journal:  Invest Ophthalmol       Date:  1974-10

Review 5.  Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.

Authors:  P F Kador; J H Kinoshita; N E Sharpless
Journal:  J Med Chem       Date:  1985-07       Impact factor: 7.446

6.  Inhibition of aldose reductase activities by kampo medicines.

Authors:  K Aida; H Shindo; M Tawata; T Onaya
Journal:  Planta Med       Date:  1987-04       Impact factor: 3.352

7.  Studies on WF-3681, a novel aldose reductase inhibitor. I. Taxonomy, fermentation, isolation and characterization.

Authors:  M Nishikawa; Y Tsurumi; T Namiki; K Yoshida; M Okuhara
Journal:  J Antibiot (Tokyo)       Date:  1987-10       Impact factor: 2.649

8.  Inhibition of lens aldose reductase by flavonoids--their possible role in the prevention of diabetic cataracts.

Authors:  S D Varma; J H Kinoshita
Journal:  Biochem Pharmacol       Date:  1976-11-15       Impact factor: 5.858

9.  Kinetic mechanism of sheep liver NADPH-dependent aldehyde reductase.

Authors:  K S De Jongh; P J Schofield; M R Edwards
Journal:  Biochem J       Date:  1987-02-15       Impact factor: 3.857

10.  Inhibition of mitochondrial respiration and production of toxic oxygen radicals by flavonoids. A structure-activity study.

Authors:  W F Hodnick; F S Kung; W J Roettger; C W Bohmont; R S Pardini
Journal:  Biochem Pharmacol       Date:  1986-07-15       Impact factor: 5.858
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