Literature DB >> 1145193

Flavonoids as inhibitors of lens aldose reductase.

S D Varma, I Mikuni, J H Kinoshita.   

Abstract

Flavonoids are effective inhibitors of lens aldose reductase. Quercetin, quercitrin, and myricitrin are significantly more potent than the previously known aldose reductase inhibitors. The inhibitory activity is of the noncompetitive type. In addition, quercitrin effectively blocks polyol accumulation in intact rat lenses incubated in medium containing high concentration of sugars.

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Year:  1975        PMID： 1145193     DOI： 10.1126/science.1145193

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  26 in total

1.  Inhibition of aldose reductase by dihydroflavonols in Engelhardtia chrysolepis and effects on other enzymes.

Authors:  H Haraguchi; I Ohmi; H Masuda; Y Tamura; K Mizutani; O Tanaka; W H Chou
Journal:  Experientia       Date:  1996-06-15

2.  Formation of advanced glycation end (AGE) products in diabetes: prevention by pyruvate and alpha-keto glutarate.

Authors:  S D Varma; P S Devamanoharan; A H Ali
Journal:  Mol Cell Biochem       Date:  1997-06       Impact factor: 3.396

3.  The UV-vis absorption spectrum of the flavonol quercetin in methanolic solution: A theoretical investigation.

Authors:  T Andrade-Filho; T C S Ribeiro; J Del Nero
Journal:  Eur Phys J E Soft Matter       Date:  2009-07-04       Impact factor: 1.890

4.  Enzymatic formation of prostaglandin F2 alpha in human brain.

Authors:  H Hayashi; Y Fujii; K Watanabe; O Hayaishi
Journal:  Neurochem Res       Date:  1990-04       Impact factor: 3.996

5.  Prevention of cataract by pyruvate in experimentally diabetic mice.

Authors:  K R Hegde; S D Varma
Journal:  Mol Cell Biochem       Date:  2005-01       Impact factor: 3.396

6.  Prevention of lens protein glycation by taurine.

Authors:  P S Devamanoharan; A H Ali; S D Varma
Journal:  Mol Cell Biochem       Date:  1997-12       Impact factor: 3.396

7.  Synthesis of 3-heteroarylchromones via a photochemical reaction.

Authors:  Qian Yang; Yun He; Tao Wang; Lingyu Zeng; Zunting Zhang
Journal:  Mol Divers       Date:  2015-07-22       Impact factor: 2.943

8.  Light-induced damage to ocular lens cation pump: prevention by vitamin C.

Authors:  S D Varma; S Kumar; R D Richards
Journal:  Proc Natl Acad Sci U S A       Date:  1979-07       Impact factor: 11.205

9.  Polyol-pathway enzymes of human brain. Partial purification and properties of sorbitol dehydrogenase.

Authors:  M M O'Brien; P J Schofield; M R Edwards
Journal:  Biochem J       Date:  1983-04-01       Impact factor: 3.857

10.  Diabetic cataract formation: potential role of glycosylation of lens crystallins.

Authors:  V J Stevens; C A Rouzer; V M Monnier; A Cerami
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205
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