Human cancers detected by proton MRS and chemical shift imaging ex vivo.

Proton magnetic resonance spectroscopy (1H MRS) has the potential to become a diagnostic adjunct for the detection and grading of human neoplastic disease. This paper describes the use of proton MRS to document changes arising in the lipid chemistry of biopsies arising from the human uterine cervix, thyroid and colon and demonstrates the diagnostic power of ex vivo spectroscopy. Proton chemical shift imaging (CSI) is further used to determine the spatial location of lipid changes in ex vivo human biopsy specimens and provides insight into the chemistry of neoplastic transformation.