Literature DB >> 8694517

Mobile lipid accumulation in necrotic tissue of high grade astrocytomas.

A C Kuesel1, K M Briere, W C Halliday, G R Sutherland, S M Donnelly, I C Smith.   

Abstract

Multiple samples from 42 astrocytomas were investigated ex vivo by 1H MR spectroscopy followed by histological assessment. MR visible lipids were detected in 27 of 32 grade 4 astrocytomas. These lipids were heterogeneously distributed within the tumours. Their amount correlated positively with the amount of histologically detected necrosis. Mobile lipids were also observed in grade 4 astrocytoma samples without necrosis, as well as in one of three grade 3, two of three grade 2 and two of four grade 1 astrocytomas. The clinical significance of MR visible lipids, their cellular location, and their possible biological bases are discussed.

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Mesh：

Year:  1996        PMID： 8694517

Source DB:  PubMed          Journal:  Anticancer Res        ISSN： 0250-7005            Impact factor:   2.480


  8 in total

1.  [Magnetic resonance spectroscopy of brain tumors].

Authors:  P Ditter; E Hattingen
Journal:  Radiologe       Date:  2017-06       Impact factor: 0.635

Review 2.  MR-visible lipids and the tumor microenvironment.

Authors:  E James Delikatny; Sanjeev Chawla; Daniel-Joseph Leung; Harish Poptani
Journal:  NMR Biomed       Date:  2011-04-27       Impact factor: 4.044

3.  Magnetic resonance spectroscopy for detection of choline kinase inhibition in the treatment of brain tumors.

Authors:  Manoj Kumar; Sean P Arlauckas; Sona Saksena; Gaurav Verma; Ranjit Ittyerah; Stephen Pickup; Anatoliy V Popov; Edward J Delikatny; Harish Poptani
Journal:  Mol Cancer Ther       Date:  2015-02-05       Impact factor: 6.261

4.  Proton magnetic resonance spectroscopy in immunocompetent patients with primary central nervous system lymphoma.

Authors:  J J Raizer; J A Koutcher; L E Abrey; K S Panageas; L M DeAngelis; E Lis; S Xu; K L Zakian
Journal:  J Neurooncol       Date:  2005-01       Impact factor: 4.130

5.  Differentiation of hemangioblastomas from pilocytic astrocytomas using 3-T magnetic resonance perfusion-weighted imaging and MR spectroscopy.

Authors:  D J She; Z Xing; Z Zeng; X Y Shang; D R Cao
Journal:  Neuroradiology       Date:  2014-12-07       Impact factor: 2.804

6.  Comparison of perfusion, diffusion, and MR spectroscopy between low-grade enhancing pilocytic astrocytomas and high-grade astrocytomas.

Authors:  M de Fatima Vasco Aragao; M Law; D Batista de Almeida; G Fatterpekar; B Delman; A S Bader; M Pelaez; M Fowkes; R Vieira de Mello; M Moraes Valenca
Journal:  AJNR Am J Neuroradiol       Date:  2014-04-03       Impact factor: 3.825

7.  Noninvasive estimation of tumour viability in a xenograft model of human neuroblastoma with proton magnetic resonance spectroscopy (1H MRS).

Authors:  M Lindskog; P Kogner; F Ponthan; P Schweinhardt; B Sandstedt; T Heiden; G Helms; C Spenger
Journal:  Br J Cancer       Date:  2003-02-10       Impact factor: 7.640

8.  In-vivo proton magnetic resonance spectroscopy in adnexal lesions.

Authors:  Seong Whi Cho; Soon Gu Cho; Jung Hee Lee; Hyung Jin Kim; Myung Kwan Lim; Jong Hwa Kim; Chang Hae Suh
Journal:  Korean J Radiol       Date:  2002 Apr-Jun       Impact factor: 3.500
  8 in total

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