Literature DB >> 8694092

Ocular findings in Down's syndrome.

R P da Cunha1, J B Moreira.   

Abstract

PURPOSE: To identify the most common ocular findings in a pediatric group of patients with Down's syndrome.
METHODS: A total of 152 children with Down's syndrome between two months and 18 years of age prospectively underwent ocular examination, including visual acuity assessment, slit-lamp biomicroscopy, ocular motility, cycloplegic retinoscopy, and ophthalmoscopy.
RESULTS: Ocular findings in decreasing prevalence were the following: upward slanting of the palpebral fissure with the outer canthus 2 mm or higher than the inner canthus (82%), epicanthal folds (61%), astigmatism (60%), iris abnormalities (52%), strabismus (38%), lacrimal system obstruction (30%), blepharitis (30%), retinal abnormalities (28%), hyperopia (26%), amblyopia (26%), nystagmus (18%), cataract (13%), and myopia (13%). Visual acuity was assessed, and the Teller acuity cards were the most useful method of examination. The patients younger than five years old had a higher prevalence of hyperopia than did those in other age groups; patients between five and 12 years old had a higher prevalence of astigmatism; and patients older than 12 years of age had more iris abnormalities, strabismus, and cataract. Myopia and myopic astigmatism were more common in the patients with cardiac malformations.
CONCLUSION: The early diagnosis of the ocular abnormalities in patients with Down's syndrome, by using Teller acuity cards in assessing visual acuity facilitates the treatment of refractive errors, strabismus, and amblyopia and may minimize handicaps.

Entities:  

Mesh:

Year:  1996        PMID: 8694092     DOI: 10.1016/s0002-9394(14)72015-x

Source DB:  PubMed          Journal:  Am J Ophthalmol        ISSN: 0002-9394            Impact factor:   5.258


  47 in total

1.  Lens defects and age-related fiber cell degeneration in a mouse model of increased AbetaPP gene dosage in Down syndrome.

Authors:  Peter H Frederikse; Xiao-Ou Ren
Journal:  Am J Pathol       Date:  2002-12       Impact factor: 4.307

2.  Apolipoprotein E polymorphism in patients with cataract.

Authors:  M Zetterberg; H Zetterberg; M Palmér; L Rymo; K Blennow; G Tasa; E Juronen; S Veromann; P Teesalu; J-O Karlsson; K Höglund
Journal:  Br J Ophthalmol       Date:  2004-05       Impact factor: 4.638

3.  Static and dynamic measurements of accommodation in individuals with down syndrome.

Authors:  Heather A Anderson; Ruth E Manny; Adrian Glasser; Karla K Stuebing
Journal:  Invest Ophthalmol Vis Sci       Date:  2011-01-05       Impact factor: 4.799

4.  [Analysis of an ophthalmic pathology cohort of human fetal eyes with regard to interesting findings].

Authors:  M C Herwig; A M Müller; F G Holz; K U Loeffler
Journal:  Ophthalmologe       Date:  2010-11       Impact factor: 1.059

5.  The Down syndrome critical region regulates retinogeniculate refinement.

Authors:  Martina Blank; Peter G Fuerst; Beth Stevens; Navid Nouri; Lowry Kirkby; Deepti Warrier; Ben A Barres; Marla B Feller; Andrew D Huberman; Robert W Burgess; Craig C Garner
Journal:  J Neurosci       Date:  2011-04-13       Impact factor: 6.167

6.  Comparison of Whole Eye versus First-Surface Astigmatism in Down Syndrome.

Authors:  Rachel Knowlton; Jason D Marsack; Norman E Leach; Ralph J Herring; Heather A Anderson
Journal:  Optom Vis Sci       Date:  2015-07       Impact factor: 1.973

7.  Visual characteristics of children with Down syndrome.

Authors:  Kaoru Tomita
Journal:  Jpn J Ophthalmol       Date:  2017-02-07       Impact factor: 2.447

8.  FE65 and FE65L1 amyloid precursor protein-binding protein compound null mice display adult-onset cataract and muscle weakness.

Authors:  Jaehong Suh; Juliet A Moncaster; Lirong Wang; Imran Hafeez; Joachim Herz; Rudolph E Tanzi; Lee E Goldstein; Suzanne Y Guénette
Journal:  FASEB J       Date:  2015-03-10       Impact factor: 5.191

9.  Alzheimer's disease amyloid-beta links lens and brain pathology in Down syndrome.

Authors:  Juliet A Moncaster; Roberto Pineda; Robert D Moir; Suqian Lu; Mark A Burton; Joy G Ghosh; Maria Ericsson; Stephanie J Soscia; Anca Mocofanescu; Rebecca D Folkerth; Richard M Robb; Jer R Kuszak; John I Clark; Rudolph E Tanzi; David G Hunter; Lee E Goldstein
Journal:  PLoS One       Date:  2010-05-20       Impact factor: 3.240

10.  Heart defects and ocular anomalies in children with Down's syndrome.

Authors:  N R Bromham; J M Woodhouse; M Cregg; E Webb; W I Fraser
Journal:  Br J Ophthalmol       Date:  2002-12       Impact factor: 4.638

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