PURPOSE: To evaluate the utility and possible increased sensitivity of fluid-attenuated inversion recovery (FLAIR) images for the detection of tubers in patients with tuberous sclerosis, compared with standard T2-weighted images, and to evaluate whether the tubers are correlated with neurologic symptoms. METHOD: We examined the number, size, and location of tubers in five tuberous sclerosis patients using T2-weighted and FLAIR images. Their intelligence quotients, ages at the onset of the first seizure, seizure types, and epileptic severity also were studied retrospectively. RESULTS: The number of tubers observed ranged from 4 to 17 on T2-weighted images, and from 10 to 33 on FLAIR images. All the tubers, other than the myelination line on T2-weighted images, were remarkably demonstrated as high-intensity lesions on FLAIR images. No correlation was found between the neurologic outcome and the number, size, or location of tubers on FLAIR images. CONCLUSION: FLAIR images were very sensitive for the detection of tubers, especially small subcortical ones, the number, size, and location of which are not related to the neurologic symptoms.
PURPOSE: To evaluate the utility and possible increased sensitivity of fluid-attenuated inversion recovery (FLAIR) images for the detection of tubers in patients with tuberous sclerosis, compared with standard T2-weighted images, and to evaluate whether the tubers are correlated with neurologic symptoms. METHOD: We examined the number, size, and location of tubers in five tuberous sclerosispatients using T2-weighted and FLAIR images. Their intelligence quotients, ages at the onset of the first seizure, seizure types, and epileptic severity also were studied retrospectively. RESULTS: The number of tubers observed ranged from 4 to 17 on T2-weighted images, and from 10 to 33 on FLAIR images. All the tubers, other than the myelination line on T2-weighted images, were remarkably demonstrated as high-intensity lesions on FLAIR images. No correlation was found between the neurologic outcome and the number, size, or location of tubers on FLAIR images. CONCLUSION: FLAIR images were very sensitive for the detection of tubers, especially small subcortical ones, the number, size, and location of which are not related to the neurologic symptoms.
Authors: U C Wieshmann; S L Free; A D Everitt; P A Bartlett; G J Barker; P S Tofts; J S Duncan; S D Shorvon; J M Stevens Journal: J Neurol Neurosurg Psychiatry Date: 1996-10 Impact factor: 10.154
Authors: Joel S Katz; Hyman Frankel; Tracy Ma; David Zagzag; Benjamin Liechty; Bruria Ben Zeev; Michal Tzadok; Orrin Devinsky; Howard L Weiner; Jonathan Roth Journal: Childs Nerv Syst Date: 2017-01-10 Impact factor: 1.475
Authors: Demet Karadag; Hans-J Mentzel; Daniel Güllmar; Tina Rating; Ulrike Löbel; Ulrich Brandl; Jürgen R Reichenbach; Werner A Kaiser Journal: Pediatr Radiol Date: 2005-06-14