BACKGROUND AND PURPOSE: Cortical and white matter changes have been identified outside the MR imaging-visible cortical/subcortical tubers in the tuberous sclerosis complex. The aim of this study was to evaluate DTI changes in the corpus callosum and internal capsules and to correlate the DTI changes with cortical/subcortical tuber load. MATERIALS AND METHODS: Twelve TSC patients and 23 controls underwent MR imaging including DTI. FA, trace, D( ||), and D() of genu and splenium of corpus callosum and right and left internal capsules were assessed. The number and volume of cortical/subcortical tubers were correlated with DTI indices of corpus callosum and internal capsules. RESULTS: In the genu and splenium, FA was lower and trace (P < .01) and D() were higher (P < .01), and in the internal capsules, trace was higher (P = .04) in TSC patients compared with controls. The total tuber volume correlated positively with trace of genu (r = 0.77, P < .01) and splenium (r = 0.69, P = .01) and with D() of splenium (r = 0.68, P = .01), and negatively with FA of splenium (r = -0.60, P = .04) of corpus callosum. The left and right hemispheric tuber volume correlated positively with trace of left (r = 0.56, P = .05) and right (r = 0.67, P = .02) internal capsules. CONCLUSIONS: Our findings of reduced FA, elevated trace, and elevated D() in the corpus callosum and internal capsules may be related to abnormalities in myelin. The correlations between tuber volume and DTI indices in corpus callosum and internal capsules suggested that more extensive malformation as demonstrated by larger tuber load was more likely to be associated with more severe DTI changes in the commissural and projection white matter.
BACKGROUND AND PURPOSE: Cortical and white matter changes have been identified outside the MR imaging-visible cortical/subcortical tubers in the tuberous sclerosis complex. The aim of this study was to evaluate DTI changes in the corpus callosum and internal capsules and to correlate the DTI changes with cortical/subcortical tuber load. MATERIALS AND METHODS: Twelve TSC patients and 23 controls underwent MR imaging including DTI. FA, trace, D( ||), and D() of genu and splenium of corpus callosum and right and left internal capsules were assessed. The number and volume of cortical/subcortical tubers were correlated with DTI indices of corpus callosum and internal capsules. RESULTS: In the genu and splenium, FA was lower and trace (P < .01) and D() were higher (P < .01), and in the internal capsules, trace was higher (P = .04) in TSC patients compared with controls. The total tuber volume correlated positively with trace of genu (r = 0.77, P < .01) and splenium (r = 0.69, P = .01) and with D() of splenium (r = 0.68, P = .01), and negatively with FA of splenium (r = -0.60, P = .04) of corpus callosum. The left and right hemispheric tuber volume correlated positively with trace of left (r = 0.56, P = .05) and right (r = 0.67, P = .02) internal capsules. CONCLUSIONS: Our findings of reduced FA, elevated trace, and elevated D() in the corpus callosum and internal capsules may be related to abnormalities in myelin. The correlations between tuber volume and DTI indices in corpus callosum and internal capsules suggested that more extensive malformation as demonstrated by larger tuber load was more likely to be associated with more severe DTI changes in the commissural and projection white matter.
Authors: Demet Karadag; Hans-J Mentzel; Daniel Güllmar; Tina Rating; Ulrike Löbel; Ulrich Brandl; Jürgen R Reichenbach; Werner A Kaiser Journal: Pediatr Radiol Date: 2005-06-14
Authors: B H Braffman; L T Bilaniuk; T P Naidich; N R Altman; M J Post; R M Quencer; R A Zimmerman; B A Brody Journal: Radiology Date: 1992-04 Impact factor: 11.105
Authors: K Ridler; E T Bullmore; P J De Vries; J Suckling; G J Barker; S J Meara; S C Williams; P F Bolton Journal: Psychol Med Date: 2001-11 Impact factor: 7.723
Authors: Jurriaan M Peters; Mustafa Sahin; Vanessa K Vogel-Farley; Shafali S Jeste; Charles A Nelson; Matthew C Gregas; Sanjay P Prabhu; Benoit Scherrer; Simon K Warfield Journal: Acad Radiol Date: 2012-01 Impact factor: 3.173
Authors: Fiona M Baumer; Jae W Song; Paul D Mitchell; Rudolph Pienaar; Mustafa Sahin; P Ellen Grant; Emi Takahashi Journal: Pediatr Neurol Date: 2015-02-16 Impact factor: 3.372
Authors: Jurriaan M Peters; Anna K Prohl; Xavier K Tomas-Fernandez; Maxime Taquet; Benoit Scherrer; Sanjay P Prabhu; Hart G Lidov; Jolene M Singh; Floor E Jansen; Kees P J Braun; Mustafa Sahin; Simon K Warfield; Aymeric Stamm Journal: Neurology Date: 2015-10-02 Impact factor: 9.910
Authors: Anastasia K Zikou; Vasileios G Xydis; Loukas G Astrakas; Iliada Nakou; Loukia C Tzarouchi; Meropi Tzoufi; Maria I Argyropoulou Journal: Pediatr Radiol Date: 2016-04-16
Authors: Marieke Klein; Marjolein van Donkelaar; Ellen Verhoef; Barbara Franke Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2017-07 Impact factor: 3.568
Authors: Jurriaan M Peters; Maxime Taquet; Anna K Prohl; Benoit Scherrer; Agnies M van Eeghen; Sanjay P Prabhu; Mustafa Sahin; Simon K Warfield Journal: Future Neurol Date: 2013-09
Authors: Kiho Im; Banu Ahtam; Daniel Haehn; Jurriaan M Peters; Simon K Warfield; Mustafa Sahin; P Ellen Grant Journal: Cereb Cortex Date: 2015-03-05 Impact factor: 5.357