Literature DB >> 8692198

Alterations of c-fos gene methylation in the processes of aging and tumorigenesis in human liver.

E K Choi1, S Uyeno, N Nishida, T Okumoto, S Fujimura, Y Aoki, M Nata, K Sagisaka, Y Fukuda, K Nakao, T Yoshimoto, Y S Kim, T Ono.   

Abstract

The state of DNA methylation in the c-fos gene was examined in human livers of different ages, cirrhosis and hepatocellular carcinoma. The degree of methylation in the intron 1 to exon 4 region increased with age, whereas all of the 10 cirrhosis samples revealed a decrease in methylation when compared to normal livers of similar ages. The 11 hepatocellular carcinomas showed varied alterations suggesting that the alteration of the c-fos gene methylation is related to aging as well as to early-step of hepatocarcinogenesis.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8692198     DOI： 10.1016/0027-5107(96)00056-5

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  15 in total

Review 1.  Epigenetic alterations in aging.

Authors:  Susana Gonzalo
Journal:  J Appl Physiol (1985)       Date:  2010-05-06

Review 2.  Epigenetic control of aging.

Authors:  Ursula Muñoz-Najar; John M Sedivy
Journal:  Antioxid Redox Signal       Date:  2010-11-22       Impact factor: 8.401

3.  A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects.

Authors:  Joseph L McClay; Karolina A Aberg; Shaunna L Clark; Srilaxmi Nerella; Gaurav Kumar; Lin Y Xie; Alexandra D Hudson; Aki Harada; Christina M Hultman; Patrik K E Magnusson; Patrick F Sullivan; Edwin J C G Van Den Oord
Journal:  Hum Mol Genet       Date:  2013-10-16       Impact factor: 6.150

4.  The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood.

Authors:  Scott M Langevin; E Andres Houseman; Brock C Christensen; John K Wiencke; Heather H Nelson; Margaret R Karagas; Carmen J Marsit; Karl T Kelsey
Journal:  Epigenetics       Date:  2011-07-01       Impact factor: 4.528

5.  Global transcriptional profiling using RNA sequencing and DNA methylation patterns in highly enriched mesenchymal cells from young versus elderly women.

Authors:  Matthew M Roforth; Joshua N Farr; Koji Fujita; Louise K McCready; Elizabeth J Atkinson; Terry M Therneau; Julie M Cunningham; Matthew T Drake; David G Monroe; Sundeep Khosla
Journal:  Bone       Date:  2015-03-27       Impact factor: 4.398

6.  Aging and epigenetics: longitudinal changes in gene-specific DNA methylation.

Authors:  Jaime Madrigano; Andrea Baccarelli; Murray A Mittleman; David Sparrow; Pantel S Vokonas; Letizia Tarantini; Joel Schwartz
Journal:  Epigenetics       Date:  2012-01-01       Impact factor: 4.528

Review 7.  DNA methylation, an epigenetic mechanism connecting folate to healthy embryonic development and aging.

Authors:  Kyong-chol Kim; Simonetta Friso; Sang-Woon Choi
Journal:  J Nutr Biochem       Date:  2009-09-04       Impact factor: 6.048

8.  DNA Hypomethylation Contributes to Genomic Instability and Intestinal Cancer Initiation.

Authors:  Karyn L Sheaffer; Ellen N Elliott; Klaus H Kaestner
Journal:  Cancer Prev Res (Phila)       Date:  2016-02-16

Review 9.  Discovery of molecular associations among aging, stem cells, and cancer based on gene expression profiling.

Authors:  Xiaosheng Wang
Journal:  Chin J Cancer       Date:  2013-01-09

10.  Microarray analysis of ageing-related signatures and their expression in tumors based on a computational biology approach.

Authors:  Xiaosheng Wang
Journal:  Genomics Proteomics Bioinformatics       Date:  2012-06-25       Impact factor: 7.691
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.