Literature DB >> 8682716

Andrastins A-C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929. I. Producing strain, fermentation, isolation, and biological activities.

S Omura1, J Inokoshi, R Uchida, K Shiomi, R Masuma, T Kawakubo, H Tanaka, Y Iwai, S Kosemura, S Yamamura.   

Abstract

New protein farnesyltransferase inhibitors, andrastins A-C, have been discovered in the cultured broth of Penicillium sp. FO-3929. Andrastins extracted from broth supernatant were purified by silica gel chromatography, ODS chromatography and HPLC. The IC50 of andrastins A, B, and C against protein farnesyltransferase were 24.9, 47.1, and 13.3 microM, respectively.

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Year:  1996        PMID： 8682716     DOI： 10.7164/antibiotics.49.414

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  6 in total

1.  Roquefortine/oxaline biosynthesis pathway metabolites in Penicillium ser. Corymbifera: in planta production and implications for competitive fitness.

Authors:  D P Overy; K F Nielsen; J Smedsgaard
Journal:  J Chem Ecol       Date:  2005-09-28       Impact factor: 2.626

2.  Atlantinone A, a Meroterpenoid Produced by Penicillium ribeum and Several Cheese Associated Penicillium Species.

Authors:  Petur W Dalsgaard; Bent O Petersen; Jens Ø Duus; Christian Zidorn; Jens C Frisvad; Carsten Christophersen; Thomas O Larsen
Journal:  Metabolites       Date:  2012-02-23

3.  Metabolomic and Transcriptomic Comparison of Solid-State and Submerged Fermentation of Penicillium expansum KACC 40815.

Authors:  Hyang Yeon Kim; Do Yeon Heo; Hye Min Park; Digar Singh; Choong Hwan Lee
Journal:  PLoS One       Date:  2016-02-10       Impact factor: 3.240

4.  Exploiting the Potential of Meroterpenoid Cyclases to Expand the Chemical Space of Fungal Meroterpenoids.

Authors:  Takaaki Mitsuhashi; Lena Barra; Zachary Powers; Volga Kojasoy; Andrea Cheng; Feng Yang; Yoshimasa Taniguchi; Takashi Kikuchi; Makoto Fujita; Dean J Tantillo; John A Porco; Ikuro Abe
Journal:  Angew Chem Int Ed Engl       Date:  2020-10-22       Impact factor: 15.336

5.  Chrysoxanthones A⁻C, Three New Xanthone⁻Chromanone Heterdimers from Sponge-Associated Penicillium chrysogenum HLS111 Treated with Histone Deacetylase Inhibitor.

Authors:  Xin Zhen; Ting Gong; Yan-Hua Wen; Dao-Jiang Yan; Jing-Jing Chen; Ping Zhu
Journal:  Mar Drugs       Date:  2018-10-01       Impact factor: 5.118

Review 6.  An overview on natural farnesyltransferase inhibitors for efficient cancer therapy.

Authors:  Xiaohan Dai; Yingni Sun; Ting Zhang; Yongfei Ming; Gao Hongwei
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051
  6 in total

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