Literature DB >> 8679691

Mosaic structures of neurotoxins produced from Clostridium botulinum types C and D organisms.

K Moriishi1, M Koura, N Abe, N Fujii, Y Fujinaga, K Inoue, K Ogumad.   

Abstract

We isolated the gene encoding a botulinum neurotoxin (BoNT) of 1285 amino acids with a molecular weight of 147,364 from the toxigenic bacteriophage d-sA of Clostridium botulinum type D strain South African (Dsa). The BoNT of Dsa (BoNT/Dsa) is composed of three regions on the basis of the homology to BoNT types C1 (BoNT/C1) and D (BoNT/D). The N-terminal (Met-1 to Val-522) and the C-terminal regions (Trp-945 to Glu-1285) have high identity to corresponding regions of BoNT/D (96% identity) and BoNT/C1 (74% identity), respectively. The core region (Pro-523 to Lys-944) is common to three toxins (83% to 92% identity). These results suggest that neurotoxins produced from Clostridium botulinum types C and D are composed in a mosaic-like fashion.

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Year:  1996        PMID： 8679691     DOI： 10.1016/0167-4781(96)00006-1

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  39 in total

1.  Unique biological activity of botulinum D/C mosaic neurotoxin in murine species.

Authors:  Keiji Nakamura; Tomoko Kohda; Yuto Shibata; Kentaro Tsukamoto; Hideyuki Arimitsu; Mitsunori Hayashi; Masafumi Mukamoto; Nobuyuki Sasakawa; Shunji Kozaki
Journal:  Infect Immun       Date:  2012-06-04       Impact factor: 3.441

2.  Genetic diversity among Botulinum Neurotoxin-producing clostridial strains.

Authors:  K K Hill; T J Smith; C H Helma; L O Ticknor; B T Foley; R T Svensson; J L Brown; E A Johnson; L A Smith; R T Okinaka; P J Jackson; J D Marks
Journal:  J Bacteriol       Date:  2006-11-17       Impact factor: 3.490

3.  The genome sequence of Clostridium botulinum type C neurotoxin-converting phage and the molecular mechanisms of unstable lysogeny.

Authors:  Yoshihiko Sakaguchi; Tetsuya Hayashi; Ken Kurokawa; Keisuke Nakayama; Kenshiro Oshima; Yukako Fujinaga; Makoto Ohnishi; Eiichi Ohtsubo; Masahira Hattori; Keiji Oguma
Journal:  Proc Natl Acad Sci U S A       Date:  2005-11-15       Impact factor: 11.205

4.  Sequence variation within botulinum neurotoxin serotypes impacts antibody binding and neutralization.

Authors:  T J Smith; J Lou; I N Geren; C M Forsyth; R Tsai; S L Laporte; W H Tepp; M Bradshaw; E A Johnson; L A Smith; J D Marks
Journal:  Infect Immun       Date:  2005-09       Impact factor: 3.441

5.  A Novel Botulinum Neurotoxin, Previously Reported as Serotype H, Has a Hybrid-Like Structure With Regions of Similarity to the Structures of Serotypes A and F and Is Neutralized With Serotype A Antitoxin.

Authors:  Susan E Maslanka; Carolina Lúquez; Janet K Dykes; William H Tepp; Christina L Pier; Sabine Pellett; Brian H Raphael; Suzanne R Kalb; John R Barr; Agam Rao; Eric A Johnson
Journal:  J Infect Dis       Date:  2015-06-10       Impact factor: 5.226

6.  Neurotoxin gene profiling of clostridium botulinum types C and D native to different countries within Europe.

Authors:  Cedric Woudstra; Hanna Skarin; Fabrizio Anniballi; Lucia Fenicia; Luca Bano; Ilenia Drigo; Miriam Koene; Marie-Hélène Bäyon-Auboyer; Jean-Philippe Buffereau; Dario De Medici; Patrick Fach
Journal:  Appl Environ Microbiol       Date:  2012-02-17       Impact factor: 4.792

7.  Novel Native and Engineered Botulinum Neurotoxins.

Authors:  Lance Steward; Mitchell F Brin; Amy Brideau-Andersen
Journal:  Handb Exp Pharmacol       Date:  2021

8.  Purification and Characterization of Recombinant Botulinum Neurotoxin Serotype FA, Also Known as Serotype H.

Authors:  Gavin Hackett; Kevin Moore; David Burgin; Fraser Hornby; Bryony Gray; Mark Elliott; Imran Mir; Matthew Beard
Journal:  Toxins (Basel)       Date:  2018-05-11       Impact factor: 4.546

9.  Enhanced detection of type C botulinum neurotoxin by the Endopep-MS assay through optimization of peptide substrates.

Authors:  Dongxia Wang; Joan Krilich; Jakub Baudys; John R Barr; Suzanne R Kalb
Journal:  Bioorg Med Chem       Date:  2015-04-10       Impact factor: 3.641

10.  Genomic sequences of six botulinum neurotoxin-producing strains representing three clostridial species illustrate the mobility and diversity of botulinum neurotoxin genes.

Authors:  Theresa J Smith; Karen K Hill; Gary Xie; Brian T Foley; Charles H D Williamson; Jeffrey T Foster; Shannon L Johnson; Olga Chertkov; Hazuki Teshima; Henry S Gibbons; Lauren A Johnsky; Mark A Karavis; Leonard A Smith
Journal:  Infect Genet Evol       Date:  2014-12-06       Impact factor: 3.342
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