Literature DB >> 8675643

Genetic instability in patients with Hodgkin's disease undergoing chemotherapy.

J M Abdallah1, D P Lombardi, I R Kirsch.   

Abstract

We have studied the effect of chemotherapy on the level of a particular kind of genetic instability in patients with Hodgkin's disease. The particular type of genetic instability assayed is exemplified by trans-rearrangements between two (rather than within one) T cell antigen receptor. 16 patients were studied during their course of treatment. Presentation samples were available for 13 of these patients; 9 of them showed an increase in the level of trans-rearrangements during their exposure to chemotherapeutic agents (P < 0.043). All patients for whom posttherapy samples were available (10 out of 16) showed a return to baseline levels of trans-rearrangements 1-5 mo after completion of therapy (P < 0.03). Thus, this assay appears to be a marker for the "destabilizing" effects of certain chemotherapeutic agents.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 8675643      PMCID： PMC185983          DOI： 10.1172/JCI118343

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  15 in total

Review 1.  A measure of genomic instability and its relevance to lymphomagenesis.

Authors:  I R Kirsch; S Lipkowitz
Journal:  Cancer Res       Date:  1992-10-01       Impact factor: 12.701

2.  Risk of second cancers after treatment for Hodgkin's disease.

Authors:  M A Tucker; C N Coleman; R S Cox; A Varghese; S A Rosenberg
Journal:  N Engl J Med       Date:  1988-01-14       Impact factor: 91.245

3.  Isolation of DNA from biological specimens without extraction with phenol.

Authors:  G J Buffone; G J Darlington
Journal:  Clin Chem       Date:  1985-01       Impact factor: 8.327

4.  Elevated frequencies of 6-thioguanine-resistant lymphocytes in multiple sclerosis patients treated with cyclophosphamide: a prospective study.

Authors:  M M Ammenheuser; J B Ward; E B Whorton; J M Killian; M S Legator
Journal:  Mutat Res       Date:  1988-03       Impact factor: 2.433

Review 5.  Lymphocyte-specific genetic instability and cancer.

Authors:  I R Kirsch; J M Abdallah; V L Bertness; M Hale; S Lipkowitz; F Lista; D P Lombardi
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1994

6.  In vivo somatic mutation in the lymphocytes of Hodgkin's disease patients.

Authors:  M Caggana; H L Liber; P M Mauch; C N Coleman; K T Kelsey
Journal:  Environ Mol Mutagen       Date:  1991       Impact factor: 3.216

7.  Interlocus V-J recombination measures genomic instability in agriculture workers at risk for lymphoid malignancies.

Authors:  S Lipkowitz; V F Garry; I R Kirsch
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-15       Impact factor: 11.205

Review 8.  Constitutional chromosome instability and cancer risk.

Authors:  S Heim; B Johansson; F Mertens
Journal:  Mutat Res       Date:  1989-07       Impact factor: 2.433

9.  An unstable nuclear matrix may contribute to genetic instability.

Authors:  K J Pienta; W S Ward
Journal:  Med Hypotheses       Date:  1994-01       Impact factor: 1.538

10.  Hybrid T cell receptor genes formed by interlocus recombination in normal and ataxia-telangiectasis lymphocytes.

Authors:  S Lipkowitz; M H Stern; I R Kirsch
Journal:  J Exp Med       Date:  1990-08-01       Impact factor: 14.307
View more
  7 in total

1.  Activation of V(D)J recombination induces the formation of interlocus joints and hybrid joints in scid pre-B-cell lines.

Authors:  S Lew; D Franco; Y Chang
Journal:  Mol Cell Biol       Date:  2000-10       Impact factor: 4.272

2.  Occurrence of TRGV-BJ hybrid gene in SV40-transformed fibroblast cell lines.

Authors:  L P G D'Arce; C L Bassi; A L Fachin; G A S Passos; E T Sakamoto-Hojo
Journal:  Genetica       Date:  2009-01-14       Impact factor: 1.082

3.  Illegitimate recombination between T cell receptor genes in humans and pigs (Sus scrofa domestica).

Authors:  Petra Musilova; Jitka Drbalova; Svatava Kubickova; Halina Cernohorska; Hana Stepanova; Jiri Rubes
Journal:  Chromosome Res       Date:  2014-07-20       Impact factor: 5.239

4.  Preferential induction of MLL(Mixed Lineage Leukemia) rearrangements in human lymphocyte cultures treated with etoposide.

Authors:  María Sol Brassesco; Ana Paula Montaldi; Elza Tiemi Sakamoto-Hojo
Journal:  Genet Mol Biol       Date:  2009-03-01       Impact factor: 1.771

5.  Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.

Authors:  H Kanzler; R Küppers; M L Hansmann; K Rajewsky
Journal:  J Exp Med       Date:  1996-10-01       Impact factor: 14.307

6.  Biomarker correlations of urinary 2,4-D levels in foresters: genomic instability and endocrine disruption.

Authors:  V F Garry; R E Tarone; I R Kirsch; J M Abdallah; D P Lombardi; L K Long; B L Burroughs; D B Barr; J S Kesner
Journal:  Environ Health Perspect       Date:  2001-05       Impact factor: 9.031

7.  Qualitatively and quantitatively similar effects of active and passive maternal tobacco smoke exposure on in utero mutagenesis at the HPRT locus.

Authors:  Stephen G Grant
Journal:  BMC Pediatr       Date:  2005-06-29       Impact factor: 2.125
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.