Literature DB >> 8672541

Phosphatase 2A regulates the responsiveness of olfactory cilia.

C Kroner1, I Boekhoff, H Breer.   

Abstract

The odorant-induced second messenger response in olfactory cilia was monitored in the presence of phosphatase modulators. Okadaic acid, a phosphatase inhibitor, attenuated the odorant-induced cAMP-response in a dose-dependent manner, half maximal inhibition was obtained at 1.5 nM okadaic acid indicating that phosphatase 2A may be involved. Protamine, a selective activator of phosphatase 2A, led to significantly stronger cAMP-responses. Western blot and immunohistochemical analysis employing specific antibodies revealed that phosphatase 2A is present in olfactory tissues in particular in olfactory cilia. The results suggest that phosphatase 2A may play a regulatory role in governing the responsiveness of olfactory neurons.

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Year:  1996        PMID： 8672541     DOI： 10.1016/0167-4889(96)00030-4

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  6 in total

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  6 in total

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