Literature DB >> 8668673

An integrated method to determine epithelial transport and bioactivity of oral drug candidates in vitro.

W Rubas1, M E Cromwell, R J Mrsny, G Ingle, K A Elias.   

Abstract

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Year:  1996        PMID： 8668673     DOI： 10.1023/a:1016060729594

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


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  9 in total

Review 1.  The use of cultured epithelial and endothelial cells for drug transport and metabolism studies.

Authors:  K L Audus; R L Bartel; I J Hidalgo; R T Borchardt
Journal:  Pharm Res       Date:  1990-05       Impact factor: 4.200

2.  Direct staining and visualization of endothelial monolayers cultured on synthetic polycarbonate filters.

Authors:  P G Phillips; M F Tsan
Journal:  J Histochem Cytochem       Date:  1988-05       Impact factor: 2.479

3.  Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability.

Authors:  I J Hidalgo; T J Raub; R T Borchardt
Journal:  Gastroenterology       Date:  1989-03       Impact factor: 22.682

4.  Comparison of the permeability characteristics of a human colonic epithelial (Caco-2) cell line to colon of rabbit, monkey, and dog intestine and human drug absorption.

Authors:  W Rubas; N Jezyk; G M Grass
Journal:  Pharm Res       Date:  1993-01       Impact factor: 4.200

5.  In vitro/in vivo models for peptide oral absorption: comparison of Caco-2 cell permeability with rat intestinal absorption of renin inhibitory peptides.

Authors:  R A Conradi; K F Wilkinson; B D Rush; A R Hilgers; M J Ruwart; P S Burton
Journal:  Pharm Res       Date:  1993-12       Impact factor: 4.200

6.  Structure-activity relationships of a synthetic pentapeptide that specifically releases growth hormone in vitro.

Authors:  C Y Bowers; F Momany; G A Reynolds; D Chang; A Hong; K Chang
Journal:  Endocrinology       Date:  1980-03       Impact factor: 4.736

7.  Growth hormone secretagogues: characterization, efficacy, and minimal bioactive conformation.

Authors:  R S McDowell; K A Elias; M S Stanley; D J Burdick; J P Burnier; K S Chan; W J Fairbrother; R G Hammonds; G S Ingle; N E Jacobsen; D L Mortensen; T E Rawson; W B Won; R G Clark; T C Somers
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-21       Impact factor: 11.205

8.  Flux measurements across Caco-2 monolayers may predict transport in human large intestinal tissue.

Authors:  W Rubas; M E Cromwell; Z Shahrokh; J Villagran; T N Nguyen; M Wellton; T H Nguyen; R J Mrsny
Journal:  J Pharm Sci       Date:  1996-02       Impact factor: 3.534

9.  In vitro characterization of four novel classes of growth hormone-releasing peptide.

Authors:  K A Elias; G S Ingle; J P Burnier; R G Hammonds; R S McDowell; T E Rawson; T C Somers; M S Stanley; M J Cronin
Journal:  Endocrinology       Date:  1995-12       Impact factor: 4.736
  9 in total
  3 in total

1.  Fatty acids and epithelial permeability: effect of conjugated linoleic acid in Caco-2 cells.

Authors:  H M Roche; A M Terres; I B Black; M J Gibney; D Kelleher
Journal:  Gut       Date:  2001-06       Impact factor: 23.059

2.  Enhanced paracellular transport of insulin can be achieved via transient induction of myosin light chain phosphorylation.

Authors:  Alistair Taverner; Ruggero Dondi; Khaled Almansour; Floriane Laurent; Siân-Eleri Owens; Ian M Eggleston; Nikoletta Fotaki; Randall J Mrsny
Journal:  J Control Release       Date:  2015-05-14       Impact factor: 9.776

3.  Rhombic organization of microvilli domains found in a cell model of the human intestine.

Authors:  Jonas Franz; Jonas Grünebaum; Marcus Schäfer; Dennis Mulac; Florian Rehfeldt; Klaus Langer; Armin Kramer; Christoph Riethmüller
Journal:  PLoS One       Date:  2018-01-10       Impact factor: 3.240
  3 in total

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