| Literature DB >> 8667356 |
H Riechers1, H P Albrecht, W Amberg, E Baumann, H Bernard, H J Böhm, D Klinge, A Kling, S Müller, M Raschack, L Unger, N Walker, W Wernet.
Abstract
A novel class of endothelin-A receptor ligands was discovered by high-throughput screening. Lead structure optimization led to highly potent antagonists which can be synthesized in a short sequence. The compounds are endothelin-A-selective, are orally available, and show a long duration of action.Mesh：
Substances：
Year: 1996 PMID： 8667356 DOI： 10.1021/jm960274q
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446