Literature DB >> 8666930

The half-life of RAG-1 protein in precursor B cells is increased in the absence of RAG-2 expression.

U Grawunder1, D G Schatz, T M Leu, A Rolink, F Melchers.   

Abstract

Site-specific recombination of immunoglobulin and T cell receptor gene segments in B and T lymphocytes is dependent on the expression of two recombinant activation genes, Rag-1 and Rag-2. Here, we show that RAG-1 protein turnover in pre-B cells depends on the expression of RAG-2. The apparent half-life of RAG-1 protein is increased when RAG-2 is not expressed in differentiating pre-B cells.

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Year:  1996        PMID： 8666930      PMCID： PMC2192496          DOI： 10.1084/jem.183.4.1731

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  35 in total

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2.  Cell cycle regulation of V(D)J recombination-activating protein RAG-2.

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Review 5.  Somatic generation of antibody diversity.

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7.  The v-abl tyrosine kinase negatively regulates NF-kappa B/Rel factors and blocks kappa gene transcription in pre-B lymphocytes.

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Authors:  C A Cuomo; S A Kirch; J Gyuris; R Brent; M A Oettinger
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10.  Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination.

Authors:  G E Taccioli; T M Gottlieb; T Blunt; A Priestley; J Demengeot; R Mizuta; A R Lehmann; F W Alt; S P Jackson; P A Jeggo
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7.  DNA-PK is essential only for coding joint formation in V(D)J recombination.

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9.  The CRL4VPRBP(DCAF1) E3 ubiquitin ligase directs constitutive RAG1 degradation in a non-lymphoid cell line.

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10.  DCAF1 (VprBP): emerging physiological roles for a unique dual-service E3 ubiquitin ligase substrate receptor.

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  10 in total

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