Literature DB >> 8662543

Persistent site-specific remodeling of a nucleosome array by transient action of the SWI/SNF complex.

T Owen-Hughes1, R T Utley, J Côté, C L Peterson, J L Workman.   

Abstract

The SWI/SNF complex participates in the restructuring of chromatin for transcription. The function of the yeast SWI/SNF complex in the remodeling of a nucleosome array has now been analyzed in vitro. Binding of the purified SWI/SNF complex to a nucleosome array disrupted multiple nucleosomes in an adenosine triphosphate-dependent reaction. However, removal of SWI/SNF left a deoxyribonuclease I-hypersensitive site specifically at a nucleosome that was bound by derivatives of the transcription factor Gal4p. Analysis of individual nucleosomes revealed that the SWI/SNF complex catalyzed eviction of histones from the Gal4-bound nucleosomes. Thus, the transient action of the SWI/SNF complex facilitated irreversible disruption of transcription factor-bound nucleosomes.

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Year:  1996        PMID： 8662543     DOI： 10.1126/science.273.5274.513

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  78 in total

1.  Stability of a human SWI-SNF remodeled nucleosomal array.

Authors:  J R Guyon; G J Narlikar; E K Sullivan; R E Kingston
Journal:  Mol Cell Biol       Date:  2001-02       Impact factor: 4.272

2.  Recruitment of the SWI/SNF chromatin remodeling complex by transcriptional activators.

Authors:  N Yudkovsky; C Logie; S Hahn; C L Peterson
Journal:  Genes Dev       Date:  1999-09-15       Impact factor: 11.361

3.  SWI-SNF-mediated nucleosome remodeling: role of histone octamer mobility in the persistence of the remodeled state.

Authors:  M Jaskelioff; I M Gavin; C L Peterson; C Logie
Journal:  Mol Cell Biol       Date:  2000-05       Impact factor: 4.272

4.  A family of chromatin remodeling factors related to Williams syndrome transcription factor.

Authors:  D A Bochar; J Savard; W Wang; D W Lafleur; P Moore; J Côté; R Shiekhattar
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-01       Impact factor: 11.205

Review 5.  ATP-dependent chromatin-remodeling complexes.

Authors:  M Vignali; A H Hassan; K E Neely; J L Workman
Journal:  Mol Cell Biol       Date:  2000-03       Impact factor: 4.272

6.  Stable remodeling of tailless nucleosomes by the human SWI-SNF complex.

Authors:  J R Guyon; G J Narlikar; S Sif; R E Kingston
Journal:  Mol Cell Biol       Date:  1999-03       Impact factor: 4.272

7.  Transcription-coupled repair in yeast is independent from ubiquitylation of RNA pol II: implications for Cockayne's syndrome.

Authors:  L Lommel; M E Bucheli; K S Sweder
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-01       Impact factor: 11.205

8.  Direct imaging of human SWI/SNF-remodeled mono- and polynucleosomes by atomic force microscopy employing carbon nanotube tips.

Authors:  G R Schnitzler; C L Cheung; J H Hafner; A J Saurin; R E Kingston; C M Lieber
Journal:  Mol Cell Biol       Date:  2001-12       Impact factor: 4.272

9.  Chromatin disruption and histone acetylation in regulation of the human immunodeficiency virus type 1 long terminal repeat by thyroid hormone receptor.

Authors:  Shao-Chung Victor Hsia; Yun-Bo Shi
Journal:  Mol Cell Biol       Date:  2002-06       Impact factor: 4.272

10.  The nucleosome remodeling complex, Snf/Swi, is required for the maintenance of transcription in vivo and is partially redundant with the histone acetyltransferase, Gcn5.

Authors:  P Sudarsanam; Y Cao; L Wu; B C Laurent; F Winston
Journal:  EMBO J       Date:  1999-06-01       Impact factor: 11.598
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