Literature DB >> 8662208

Sensitivity of sup35 and sup45 suppressor mutants in Saccharomyces cerevisiae to the anti-microtubule drug benomyl.

V L Tikhomirova1, S G Inge-Vechtomov.   

Abstract

SUP35 and SUP45 genes determine the accuracy of translation at the stage of termination. We present indirect evidence indicating that these genes may also control some cellular process mediated by microtubules. A majority of sup35 and sup45 suppressor mutations confer supersensitivity to benomyl, the drug which de-polymerizes microtubules. In addition, data correlating phenotypic manifestations of sup45 suppressor mutations, involving sensitivity to benomyl, respiratory deficiency and a suppressor effect, are also presented.

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Year:  1996        PMID： 8662208     DOI： 10.1007/s002940050098

Source DB:  PubMed          Journal:  Curr Genet        ISSN： 0172-8083            Impact factor:   3.886


  10 in total

1.  Mutations in eukaryotic release factors 1 and 3 act as general nonsense suppressors in Drosophila.

Authors:  Anna T Chao; Herman A Dierick; Tracie M Addy; Amy Bejsovec
Journal:  Genetics       Date:  2003-10       Impact factor: 4.562

2.  Gene overexpression as a tool for identifying new trans-acting factors involved in translation termination in Saccharomyces cerevisiae.

Authors:  Olivier Namy; Isabelle Hatin; Guillaume Stahl; Hongmei Liu; Stephanie Barnay; Laure Bidou; Jean-Pierre Rousset
Journal:  Genetics       Date:  2002-06       Impact factor: 4.562

3.  The impact of manipulations with cytoplasmically inherited factors on nuclear transmission and degradation in yeast heterokaryons.

Authors:  Olga V Nevzglyadova; Alexey V Artyomov; Ekaterina V Mikhailova; Tonu R Soidla
Journal:  Curr Genet       Date:  2004-03-13       Impact factor: 3.886

4.  Cosuppression of eukaryotic release factor 1-1 in Arabidopsis affects cell elongation and radial cell division.

Authors:  Katherine Anne Petsch; Joshua Mylne; José Ramón Botella
Journal:  Plant Physiol       Date:  2005-08-19       Impact factor: 8.340

5.  Functional role of Tia1/Pub1 and Sup35 prion domains: directing protein synthesis machinery to the tubulin cytoskeleton.

Authors:  Xiang Li; Joseph B Rayman; Eric R Kandel; Irina L Derkatch
Journal:  Mol Cell       Date:  2014-06-26       Impact factor: 17.970

6.  Prion-dependent switching between respiratory competence and deficiency in the yeast nam9-1 mutant.

Authors:  A Chacinska; M Boguta; J Krzewska; S Rospert
Journal:  Mol Cell Biol       Date:  2000-10       Impact factor: 4.272

7.  Genetic study of interactions between the cytoskeletal assembly protein sla1 and prion-forming domain of the release factor Sup35 (eRF3) in Saccharomyces cerevisiae.

Authors:  P A Bailleul; G P Newnam; J N Steenbergen; Y O Chernoff
Journal:  Genetics       Date:  1999-09       Impact factor: 4.562

8.  Identification of the genes encoding the cytosolic translation release factors from Podospora anserina and analysis of their role during the life cycle.

Authors:  B Gagny; P Silar
Journal:  Genetics       Date:  1998-08       Impact factor: 4.562

9.  Human eukaryotic release factor 3a depletion causes cell cycle arrest at G1 phase through inhibition of the mTOR pathway.

Authors:  Céline Chauvin; Samia Salhi; Olivier Jean-Jean
Journal:  Mol Cell Biol       Date:  2007-06-11       Impact factor: 4.272

10.  Decoding accuracy in eRF1 mutants and its correlation with pleiotropic quantitative traits in yeast.

Authors:  Gloria H Merritt; Wesley R Naemi; Pierre Mugnier; Helen M Webb; Mick F Tuite; Tobias von der Haar
Journal:  Nucleic Acids Res       Date:  2010-05-05       Impact factor: 16.971
  10 in total

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