Literature DB >> 866172

Levels of DNA polymerase-alpha and beta in normal and xeroderma pigmentosum fibroblasts.

U Bertazzoni, M Stefanini, G Pedrali-Noy, F Nuzzo, A Falaschi.   

Abstract

We have determined the levels of DNA-polymerases-alpha and-beta in fibroblasts obtained from normal subjects and from patients with Xeroderma Pigmentosum (XP) belonging to three different complementation groups and to the variant form. The assays have been performed in crude extracts and after fractionation on sucrose gradients. The levels of alpha and beta-polymerases in the different cases of XP were found to lie within the same range as the control values, and no correlation was found with the severity of the symptoms. The sedimentation coefficients of the two polymerases from all the pathological lines were identical to those of the normal fibroblasts.

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Year:  1977        PMID： 866172      PMCID： PMC342415          DOI： 10.1093/nar/4.1.141

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  26 in total

Review 1.  Mammalian DNA polymerases.

Authors:  F J Bollum
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  1975

2.  Nomenclature of eukaryotic DNA polymerases.

Authors:  A Weissbach; D Baltimore; F Bollum; R Gallo; D Korn
Journal:  Eur J Biochem       Date:  1975-11-01

3.  Low levels of photoreactivating enzyme in xeroderma pigmentosum variants.

Authors:  B M Sutherland; R Oliver
Journal:  Nature       Date:  1975-09-11       Impact factor: 49.962

4.  Genetic heterogeneity in xeroderma pigmentosum: complementation groups and their relationship to DNA repair rates.

Authors:  K H Kraemer; H G Coon; R A Petinga; S F Barrett; A E Rahe; J H Robbins
Journal:  Proc Natl Acad Sci U S A       Date:  1975-01       Impact factor: 11.205

5.  A UV-specific endonucleolytic activity present in human cell extracts.

Authors:  S Bacchetti; A van der Plas; G Veldhuisen
Journal:  Biochem Biophys Res Commun       Date:  1972-08-07       Impact factor: 3.575

6.  HeLa cell R-deoxyribonucleic acid polymerases. Separation and characterization of two enzymatic activities.

Authors:  S Spadari; A Weissbach
Journal:  J Biol Chem       Date:  1974-09-25       Impact factor: 5.157

7.  Genetic heterogeneity of xeroderma pigmentosum demonstrated by somatic cell hybridization.

Authors:  E A De Weerd-Kastelein; W Keijzer; D Bootsma
Journal:  Nat New Biol       Date:  1972-07-19

8.  Repair enzyme suggested by mammalian endonuclease activity specific for ultraviolet-irradiated DNA.

Authors:  T P Brent
Journal:  Nat New Biol       Date:  1972-10-11

9.  Xeroderma pigmentosum: variants with normal DNA repair and normal sensitivity to ultraviolet light.

Authors:  J E Cleaver
Journal:  J Invest Dermatol       Date:  1972-03       Impact factor: 8.551

10.  Levels of some enzymes acting on DNA in xeroderma pigmentosum.

Authors:  A M Pedrini; L Dalpra; G Ciarrocchi; G C Noy; S Spadari; F Nuzzo; A Falaschi
Journal:  Nucleic Acids Res       Date:  1974-02       Impact factor: 16.971
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  5 in total

1.  Levels of DNA polymerases alpha, beta, and gamma in control and repair-deficient human diploid fibroblasts 1.

Authors:  V P Parker; M W Lieberman
Journal:  Nucleic Acids Res       Date:  1977-06       Impact factor: 16.971

2.  A cell-free assay measuring repair DNA synthesis in human fibroblasts.

Authors:  G Ciarrocchi; S Linn
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

3.  Isolation and characterization of monoclonal antibodies directed against the DNA repair enzyme uracil DNA glycosylase from human placenta.

Authors:  P Arenaz; M A Sirover
Journal:  Proc Natl Acad Sci U S A       Date:  1983-10       Impact factor: 11.205

4.  DNA polymerases alpha beta and gamma in inherited diseases affecting DNA repair.

Authors:  U Bertazzoni; A I Scovassi; M Stefanini; E Giulotto; S Spadari; A M Pedrini
Journal:  Nucleic Acids Res       Date:  1978-06       Impact factor: 16.971

5.  Differential susceptibilities of DNA polymerases-alpha and -beta to polyanions.

Authors:  T Shimada; M Yamada; M Miwa; H Nagano; Y Mano
Journal:  Nucleic Acids Res       Date:  1978-09       Impact factor: 16.971
  5 in total

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