Literature DB >> 8661102

Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene.

I Pecker1, K B Avraham, D J Gilbert, K Savitsky, G Rotman, R Harnik, T Fukao, E Schröck, S Hirotsune, D A Tagle, F S Collins, A Wynshaw-Boris, T Ried, N G Copeland, N A Jenkins, Y Shiloh, Y Ziv.   

Abstract

Atm, the mouse homolog of the human ATM gene defective in ataxia-telangiectasia (A-T), has been identified. The entire coding sequence of the Atm transcript was cloned and found to contain an open reading frame encoding a protein of 3066 amino acids with 84% overall identity and 91% similarity to the human ATM protein. Variable levels of expression of Atm were observed in different tissues. Fluorescence in situ hybridization and linkage analysis located the Atm gene on mouse chromosome 9, band 9C, in a region homologous to the ATM region on human chromosome 11q22-q23.

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Year:  1996        PMID： 8661102     DOI： 10.1006/geno.1996.0320

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  7 in total

Review 1.  [Evaluation of cancer risk through genetic analysis?].

Authors:  A Luz
Journal:  Strahlenther Onkol       Date:  1997-09       Impact factor: 3.621

2.  Stem Cells in Aging: Influence of Ontogenic, Genetic and Environmental Factors.

Authors:  Edmond J Yunis; Joaquin Zúñiga; Prasad S Koka; Zaheed Husain; Viviana Romero; Joel N H Stern; Masha Fridkis-Hareli
Journal:  J Stem Cells       Date:  2006

3.  A novel porcine model of ataxia telangiectasia reproduces neurological features and motor deficits of human disease.

Authors:  Rosanna Beraldi; Chun-Hung Chan; Christopher S Rogers; Attila D Kovács; David K Meyerholz; Constantin Trantzas; Allyn M Lambertz; Benjamin W Darbro; Krystal L Weber; Katherine A M White; Richard V Rheeden; Michael C Kruer; Brian A Dacken; Xiao-Jun Wang; Bryan T Davis; Judy A Rohret; Jason T Struzynski; Frank A Rohret; Jill M Weimer; David A Pearce
Journal:  Hum Mol Genet       Date:  2015-09-15       Impact factor: 6.150

4.  Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2.

Authors:  H Rothe; N A Jenkins; N G Copeland; H Kolb
Journal:  J Clin Invest       Date:  1997-02-01       Impact factor: 14.808

5.  Pleiotropic defects in ataxia-telangiectasia protein-deficient mice.

Authors:  A Elson; Y Wang; C J Daugherty; C C Morton; F Zhou; J Campos-Torres; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1996-11-12       Impact factor: 11.205

6.  Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae.

Authors:  J M Sidorova; L L Breeden
Journal:  Genes Dev       Date:  1997-11-15       Impact factor: 11.361

Review 7.  ATM-NF-kappaB connection as a target for tumor radiosensitization.

Authors:  Kazi Mokim Ahmed; Jian Jian Li
Journal:  Curr Cancer Drug Targets       Date:  2007-06       Impact factor: 3.428
  7 in total

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