Literature DB >> 8655212

In vitro activity of cefpirome against selected clinical enterobacterial isolates with beta-lactamase-mediated resistance.

L S Tzouvelekis1, E Tzelepi, A F Mentis, N J Legakis.   

Abstract

Previous studies have shown that there is a high incidence of resistance to cephalosporins among enterobacteria isolated in Greek hospitals. This resistance is mainly due to either the derepression of chromosomal cephalosporinases or the acquisition of plasmids coding for SHV-5 type beta-lactamase. In the present study the activity of cefpirome against a number of enterobacteria (Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Enterobacter aerogenes and Serratia marcescens) possessing the mechanisms mentioned above was examined. Cefpirome was found active against all the strains characterized by stable derepression of chromosomal class-C enzymes. The antibiotic was less potent against strains expressing SHV-5 type beta-lactamase due to its hydrolysis by the enzyme. Also cefpirome exhibited good activity against E. aerogenes strains with reduced susceptibility to imipenem. These in vitro data suggest that cefpirome might be useful in treating infections caused by these resistant microorganisms that are frequently encountered in Greek hospitals.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 8655212     DOI： 10.1007/bf01713572

Source DB:  PubMed          Journal:  Infection        ISSN： 0300-8126            Impact factor:   3.553


  20 in total

1.  Prevalence of a transferable SHV-5 type beta-lactamase in clinical isolates of Klebsiella pneumoniae and Escherichia coli in Greece.

Authors:  A C Vatopoulos; A Philippon; L S Tzouvelekis; Z Komninou; N J Legakis
Journal:  J Antimicrob Chemother       Date:  1990-11       Impact factor: 5.790

2.  Antibiotic resistance among gram-negative bacilli in 19 Greek hospitals.

Authors: 
Journal:  J Hosp Infect       Date:  1989-08       Impact factor: 3.926

3.  Nucleotide sequence of a plasmid-mediated cephalosporinase gene (blaLAT-1) found in Klebsiella pneumoniae.

Authors:  L S Tzouvelekis; E Tzelepi; A F Mentis
Journal:  Antimicrob Agents Chemother       Date:  1994-09       Impact factor: 5.191

4.  High prevalence of stably derepressed class-I beta-lactamase expression in multiresistant clinical isolates of Enterobacter cloacae from Greek hospitals.

Authors:  E Tzelepi; L S Tzouvelekis; A C Vatopoulos; A F Mentis; A Tsakris; N J Legakis
Journal:  J Med Microbiol       Date:  1992-08       Impact factor: 2.472

5.  Imipenem resistance in Enterobacter aerogenes is associated with derepression of chromosomal cephalosporinases and impaired permeability.

Authors:  L S Tzouvelekis; E Tzelepi; A F Mentis; A C Vatopoulos; A Tsakris
Journal:  FEMS Microbiol Lett       Date:  1992-08-15       Impact factor: 2.742

6.  Identification of a novel plasmid-mediated beta-lactamase with chromosomal cephalosporinase characteristics from Klebsiella pneumoniae.

Authors:  L S Tzouvelekis; E Tzelepi; A F Mentis; A Tsakris
Journal:  J Antimicrob Chemother       Date:  1993-05       Impact factor: 5.790

7.  Diversity of aminoglycoside resistance in Enterobacter cloacae in Greece.

Authors:  A C Vatopoulos; A Tsakris; L S Tzouvelekis; N J Legakis; T L Pitt; G H Miller; K J Shaw; M Antreou; M Nikolopoulou; Z Komninou
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1992-02       Impact factor: 3.267

8.  Dissemination of cephalosporin-resistant Serratia marcescens strains producing a plasmidic SHV type beta-lactamase in Greek hospitals.

Authors:  D Gianneli; E Tzelepi; L S Tzouvelekis; A F Mentis; C Nikolopoulou
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1994-09       Impact factor: 3.267

9.  The in vitro activity and beta-lactamase stability of cefpirome (HR 810), a pyridine cephalosporin agent active against staphylococci, Enterobacteriaceae and Pseudomonas aeruginosa.

Authors:  H C Neu; N X Chin; P Labthavikul
Journal:  Infection       Date:  1985 May-Jun       Impact factor: 3.553

10.  Interaction of cefpirome and a cephalosporinase from Citrobacter freundii GN7391.

Authors:  S Satake; M Hiraoka; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1989-03       Impact factor: 5.191
View more
  3 in total

1.  Sporadic emergence of Klebsiella pneumoniae strains resistant to cefepime and cefpirome in Greek hospitals.

Authors:  L S Tzouvelekis; E Tzelepi; E Prinarakis; M Gazouli; A Katrahoura; P Giakkoupi; O Paniara; N J Legakis
Journal:  J Clin Microbiol       Date:  1998-01       Impact factor: 5.948

Review 2.  Cefpirome. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy in the treatment of severe nosocomial infections and febrile neutropenia.

Authors:  L R Wiseman; H M Lamb
Journal:  Drugs       Date:  1997-07       Impact factor: 9.546

3.  Cefepime, piperacillin-tazobactam, and the inoculum effect in tests with extended-spectrum beta-lactamase-producing Enterobacteriaceae.

Authors:  K S Thomson; E S Moland
Journal:  Antimicrob Agents Chemother       Date:  2001-12       Impact factor: 5.191
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.