Literature DB >> 1526451

Imipenem resistance in Enterobacter aerogenes is associated with derepression of chromosomal cephalosporinases and impaired permeability.

L S Tzouvelekis1, E Tzelepi, A F Mentis, A C Vatopoulos, A Tsakris.   

Abstract

Enterobacter aerogenes mutants with high-level resistance to imipenem were studied. They were derived from strains characterized by stable over-production of a class-I beta-lactamase. This enzyme (pI = 8.2) exhibited high affinity toward imipenem and hydrolysed the drug slowly. Imipenem-resistant mutants lacked a major 43-kDa outer membrane protein and displayed decreased permeability to cephaloridine. Introduction of a plasmid coding for the regulatory ampD gene abolished beta-lactamase production and rendered the mutants susceptible to imipenem.

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Year:  1992        PMID： 1526451     DOI： 10.1016/0378-1097(92)90428-q

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  9 in total

1.  In vitro activity of cefpirome against selected clinical enterobacterial isolates with beta-lactamase-mediated resistance.

Authors:  L S Tzouvelekis; E Tzelepi; A F Mentis; N J Legakis
Journal:  Infection       Date:  1995 Nov-Dec       Impact factor: 3.553

2.  Prevalence of outer membrane porin alteration in beta-lactam-antibiotic-resistant Enterobacter aerogenes.

Authors:  R N Charrel; J M Pagès; P De Micco; M Mallea
Journal:  Antimicrob Agents Chemother       Date:  1996-12       Impact factor: 5.191

3.  Carbapenem resistance in a clinical isolate of Citrobacter freundii.

Authors:  J L Mainardi; P Mugnier; A Coutrot; A Buu-Hoï; E Collatz; L Gutmann
Journal:  Antimicrob Agents Chemother       Date:  1997-11       Impact factor: 5.191

4.  Molecular epidemiology of an outbreak of multidrug-resistant Enterobacter aerogenes infections and in vivo emergence of imipenem resistance.

Authors:  Y De Gheldre; N Maes; F Rost; R De Ryck; P Clevenbergh; J L Vincent; M J Struelens
Journal:  J Clin Microbiol       Date:  1997-01       Impact factor: 5.948

5.  Carbapenem resistance in a clinical isolate of Enterobacter aerogenes is associated with decreased expression of OmpF and OmpC porin analogs.

Authors:  Hesna Yigit; Gregory J Anderson; James W Biddle; Christine D Steward; J Kamile Rasheed; Lourdes L Valera; John E McGowan; Fred C Tenover
Journal:  Antimicrob Agents Chemother       Date:  2002-12       Impact factor: 5.191

6.  Epidemiological study of an outbreak due to multidrug-resistant Enterobacter aerogenes in a medical intensive care unit.

Authors:  C Arpin; C Coze; A M Rogues; J P Gachie; C Bebear; C Quentin
Journal:  J Clin Microbiol       Date:  1996-09       Impact factor: 5.948

7.  Successive emergence of extended-spectrum beta-lactamase-producing and carbapenemase-producing Enterobacter aerogenes isolates in a university hospital.

Authors:  M Biendo; B Canarelli; D Thomas; F Rousseau; F Hamdad; C Adjide; G Laurans; F Eb
Journal:  J Clin Microbiol       Date:  2008-01-30       Impact factor: 5.948

Review 8.  AmpC beta-lactamases.

Authors:  George A Jacoby
Journal:  Clin Microbiol Rev       Date:  2009-01       Impact factor: 26.132

9.  Relative importances of outer membrane permeability and group 1 beta-lactamase as determinants of meropenem and imipenem activities against Enterobacter cloacae.

Authors:  G Cornaglia; K Russell; G Satta; R Fontana
Journal:  Antimicrob Agents Chemother       Date:  1995-02       Impact factor: 5.191
  9 in total

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