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Literature DB >> 8649408

Differential control of transcription by homologous homeodomain coregulators.

Abstract

The human herpes simplex virus type 1 (HSV-1) transactivator VP16 and its homolog from bovine herpes-virus 1 (BHV-1) can each recruit the human homeodomain protein Oct-1 into a transcriptional regulatory complex. Here, we show that these two Oct-1 coregulators possess similar, if not identical, homeodomain recognition properties but possess different virus-specific cis-regulatory specificities: the HSV-1 VP-16 protein activates transcription from the HSV-1 VP16 response element, and the BHV-1 VP16 protein activates transcription from the BHV-1 VP16 response element. A distinct 3-bp segment, the D segment, lying 3' of the canonical TAATGARAT motif (where R is a purine) in the VP16 response element is responsible for the differential cis element recognition and transcriptional activation by these two homeodomain coregulators. These results demonstrate how a single homeodomain protein can direct differential transcriptional regulation by selective association with homologous homeodomain coregulators.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1996 PMID： 8649408 PMCID： PMC231291 DOI： 10.1128/MCB.16.6.2967

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

36 in total

1. Recognition of the surface of a homeo domain protein.

Authors: J L Pomerantz; T M Kristie; P A Sharp
Journal: Genes Dev Date: 1992-11 Impact factor: 11.361

2. A single amino acid exchange transfers VP16-induced positive control from the Oct-1 to the Oct-2 homeo domain.

Authors: J S Lai; M A Cleary; W Herr
Journal: Genes Dev Date: 1992-11 Impact factor: 11.361

3. Differential positive control by Oct-1 and Oct-2: activation of a transcriptionally silent motif through Oct-1 and VP16 corecruitment.

Authors: M A Cleary; S Stern; M Tanaka; W Herr
Journal: Genes Dev Date: 1993-01 Impact factor: 11.361

4. A short, disordered protein region mediates interactions between the homeodomain of the yeast alpha 2 protein and the MCM1 protein.

Authors: A K Vershon; A D Johnson
Journal: Cell Date: 1993-01-15 Impact factor: 41.582

5. Interaction between two homeodomain proteins is specified by a short C-terminal tail.

Authors: M R Stark; A D Johnson
Journal: Nature Date: 1994-09-29 Impact factor: 49.962

6. The extreme carboxyl terminus of the equine herpesvirus 1 homolog of herpes simplex virus VP16 is essential for immediate-early gene activation.

Authors: G D Elliott
Journal: J Virol Date: 1994-08 Impact factor: 5.103

7. Protein and DNA elements involved in transactivation of the promoter of the bovine herpesvirus (BHV) 1 IE-1 transcription unit by the BHV alpha gene trans-inducing factor.

Authors: V Misra; A C Bratanich; D Carpenter; P O'Hare
Journal: J Virol Date: 1994-08 Impact factor: 5.103

8. The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein.

Authors: A C Wilson; K LaMarco; M G Peterson; W Herr
Journal: Cell Date: 1993-07-16 Impact factor: 41.582

9. Equid herpesviruses 1 and 4 encode functional homologs of the herpes simplex virus type 1 virion transactivator protein, VP16.

Authors: A S Purewal; R Allsopp; M Riggio; E A Telford; S Azam; A J Davison; N Edington
Journal: Virology Date: 1994-01 Impact factor: 3.616

10. Varicella-zoster virus open reading frame 10 protein, the herpes simplex virus VP16 homolog, transactivates herpesvirus immediate-early gene promoters.

Authors: H Moriuchi; M Moriuchi; S E Straus; J I Cohen
Journal: J Virol Date: 1993-05 Impact factor: 5.103

16 in total

1. Distinctions between bovine herpesvirus 1 and herpes simplex virus type 1 VP22 tegument protein subcellular associations.

Authors: J S Harms; X Ren; S C Oliveira; G A Splitter
Journal: J Virol Date: 2000-04 Impact factor: 5.103

2. Synergistic activation of the fibroblast growth factor 4 enhancer by Sox2 and Oct-3 depends on protein-protein interactions facilitated by a specific spatial arrangement of factor binding sites.

Authors: D C Ambrosetti; C Basilico; L Dailey
Journal: Mol Cell Biol Date: 1997-11 Impact factor: 4.272

3. Repression of gonadotropin-releasing hormone promoter activity by the POU homeodomain transcription factor SCIP/Oct-6/Tst-1: a regulatory mechanism of phenotype expression?

Authors: M E Wierman; X Xiong; J K Kepa; A J Spaulding; B M Jacobsen; Z Fang; G Nilaver; S R Ojeda
Journal: Mol Cell Biol Date: 1997-03 Impact factor: 4.272

Differential control of transcription by homologous homeodomain coregulators.

1. Recognition of the surface of a homeo domain protein.

2. A single amino acid exchange transfers VP16-induced positive control from the Oct-1 to the Oct-2 homeo domain.

3. Differential positive control by Oct-1 and Oct-2: activation of a transcriptionally silent motif through Oct-1 and VP16 corecruitment.

4. A short, disordered protein region mediates interactions between the homeodomain of the yeast alpha 2 protein and the MCM1 protein.

5. Interaction between two homeodomain proteins is specified by a short C-terminal tail.

6. The extreme carboxyl terminus of the equine herpesvirus 1 homolog of herpes simplex virus VP16 is essential for immediate-early gene activation.

7. Protein and DNA elements involved in transactivation of the promoter of the bovine herpesvirus (BHV) 1 IE-1 transcription unit by the BHV alpha gene trans-inducing factor.

8. The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein.

9. Equid herpesviruses 1 and 4 encode functional homologs of the herpes simplex virus type 1 virion transactivator protein, VP16.

10. Varicella-zoster virus open reading frame 10 protein, the herpes simplex virus VP16 homolog, transactivates herpesvirus immediate-early gene promoters.

1. Distinctions between bovine herpesvirus 1 and herpes simplex virus type 1 VP22 tegument protein subcellular associations.

2. Synergistic activation of the fibroblast growth factor 4 enhancer by Sox2 and Oct-3 depends on protein-protein interactions facilitated by a specific spatial arrangement of factor binding sites.

3. Repression of gonadotropin-releasing hormone promoter activity by the POU homeodomain transcription factor SCIP/Oct-6/Tst-1: a regulatory mechanism of phenotype expression?

4. OCA-B is a functional analog of VP16 but targets a separate surface of the Oct-1 POU domain.

5. Structural flexibility in transcription complex formation revealed by protein-DNA photocrosslinking.

6. Interdigitated residues within a small region of VP16 interact with Oct-1, HCF, and DNA.

7. Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism.

8. Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP.

9. DNA recognition by the herpes simplex virus transactivator VP16: a novel DNA-binding structure.

10. Crystal structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16.