| Literature DB >> 8645574 |
E A Eno-Amooquaye1, F Searle, J A Boden, S K Sharma, P J Burke.
Abstract
Polyethylene glycol modification of the antibody--enzyme conjugate, F(ab')2-A5B7-CPG2, extends its duration in the circulation of nude mice bearing human colonic cancer xenografts (LS174T). Increased concentration of modified conjugate is achieved in the tumour, but residual non-specific enzyme concentrations in normal tissue and blood demonstrate the fundamental requirement to remove or inactivate non-specifically held enzyme in this system.Entities:
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Year: 1996 PMID： 8645574 PMCID： PMC2074478 DOI： 10.1038/bjc.1996.253
Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640