Literature DB >> 3494243

Chemical modification of recombinant interleukin 2 by polyethylene glycol increases its potency in the murine Meth A sarcoma model.

N V Katre, M J Knauf, W J Laird.   

Abstract

Recombinant human interleukin 2 purified from Escherichia coli has limited solubility at neutral pH and a short circulatory half-life. This recombinant interleukin 2 was chemically modified by an active ester of polyethylene glycol. The modified interleukin 2 was purified by hydrophobic interaction chromatography and characterized by sodium dodecyl sulfate/polyacrylamide gel electrophoresis and isoelectric focusing. This conjugate was compared to unmodified recombinant interleukin 2 in vitro and in vivo. Covalent attachment of the hydrophilic polymer polyethylene glycol enhanced the solubility of interleukin 2, decreased its plasma clearance, and increased its antitumor potency in the Meth A murine sarcoma model.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3494243      PMCID： PMC304459          DOI： 10.1073/pnas.84.6.1487

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  26 in total

Review 1.  Renal filtration, transport, and metabolism of low-molecular-weight proteins: a review.

Authors:  T Maack; V Johnson; S T Kau; J Figueiredo; D Sigulem
Journal:  Kidney Int       Date:  1979-09       Impact factor: 10.612

2.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

3.  Human interleukin 2.

Authors:  R J Robb
Journal:  Methods Enzymol       Date:  1985       Impact factor: 1.600

4.  T cell growth factor: parameters of production and a quantitative microassay for activity.

Authors:  S Gillis; M M Ferm; W Ou; K A Smith
Journal:  J Immunol       Date:  1978-06       Impact factor: 5.422

5.  Rapid spectrophotometric assay of dodecyl sulfate using acridine orange.

Authors:  R L Sokoloff; R P Frigon
Journal:  Anal Biochem       Date:  1981-11-15       Impact factor: 3.365

6.  New developments in isoelectric focusing.

Authors:  P G Righetti; E Gianazza
Journal:  J Chromatogr       Date:  1980-11-07

7.  A spectrophotometric assay for soluble and immobilized N-hydroxysuccinimide esters.

Authors:  T Miron; M Wilchek
Journal:  Anal Biochem       Date:  1982-11-01       Impact factor: 3.365

8.  Clearance of interleukin 2 from the blood of normal and T cell-depleted mice.

Authors:  P F Mühlradt; H G Opitz
Journal:  Eur J Immunol       Date:  1982-11       Impact factor: 5.532

9.  Protein thiolation and reversible protein-protein conjugation. N-Succinimidyl 3-(2-pyridyldithio)propionate, a new heterobifunctional reagent.

Authors:  J Carlsson; H Drevin; R Axén
Journal:  Biochem J       Date:  1978-09-01       Impact factor: 3.857

10.  Continuous proliferation of murine antigen-specific helper T lymphocytes in culture.

Authors:  J Watson
Journal:  J Exp Med       Date:  1979-12-01       Impact factor: 14.307
View more
  33 in total

1.  Sodium chloride enhances the storage and conformational stability of BDNF and PEG-BDNF.

Authors:  W J Callahan; L O Narhi; A A Kosky; M J Treuheit
Journal:  Pharm Res       Date:  2001-03       Impact factor: 4.200

2.  Interleukin 2 acts as an adjuvant to increase the potency of inactivated rabies virus vaccine.

Authors:  J H Nunberg; M V Doyle; S M York; C J York
Journal:  Proc Natl Acad Sci U S A       Date:  1989-06       Impact factor: 11.205

3.  Treatment of idiopathic CD4 T lymphocytopenia with IL-2.

Authors:  C Cunningham-Rundles; H W Murray; J P Smith
Journal:  Clin Exp Immunol       Date:  1999-05       Impact factor: 4.330

4.  Pegylated alpha interferon is an effective treatment for virulent venezuelan equine encephalitis virus and has profound effects on the host immune response to infection.

Authors:  R A Lukaszewski; T J Brooks
Journal:  J Virol       Date:  2000-06       Impact factor: 5.103

5.  Targeting ALDH(bright) human carcinoma-initiating cells with ALDH1A1-specific CD8⁺ T cells.

Authors:  Carmen Visus; Yangyang Wang; Antonio Lozano-Leon; Robert L Ferris; Susan Silver; Miroslaw J Szczepanski; Randall E Brand; Cristina R Ferrone; Theresa L Whiteside; Soldano Ferrone; Albert B DeLeo; Xinhui Wang
Journal:  Clin Cancer Res       Date:  2011-08-19       Impact factor: 12.531

6.  Interleukin-2-containing liposomes: interaction of interleukin-2 with liposomal bilayers and preliminary studies on application in cancer vaccines.

Authors:  J J Bergers; W Den Otter; H F Dullens; C T Kerkvliet; D J Crommelin
Journal:  Pharm Res       Date:  1993-12       Impact factor: 4.200

7.  Release of human serum albumin from poly(lactide-co-glycolide) microspheres.

Authors:  M S Hora; R K Rana; J H Nunberg; T R Tice; R M Gilley; M E Hudson
Journal:  Pharm Res       Date:  1990-11       Impact factor: 4.200

8.  PEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced spinal cord distribution.

Authors:  Ryan G Soderquist; Erin D Milligan; Evan M Sloane; Jacqueline A Harrison; Klarika K Douvas; Joseph M Potter; Travis S Hughes; Raymond A Chavez; Kirk Johnson; Linda R Watkins; Melissa J Mahoney
Journal:  J Biomed Mater Res A       Date:  2009-12       Impact factor: 4.396

9.  Site-specific PEGylation enhances the pharmacokinetic properties and antitumor activity of interferon beta-1b.

Authors:  Ji I Lee; Stephen P Eisenberg; Mary S Rosendahl; Elizabeth A Chlipala; Jacquelyn D Brown; Daniel H Doherty; George N Cox
Journal:  J Interferon Cytokine Res       Date:  2013-08-20       Impact factor: 2.607

Review 10.  Cytokine combinations in immunotherapy for solid tumors: a review.

Authors:  K M Heaton; E A Grimm
Journal:  Cancer Immunol Immunother       Date:  1993-09       Impact factor: 6.968
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.