Literature DB >> 8644741

Genetic mapping of hereditary mixed polyposis syndrome to chromosome 6q.

H J Thomas1, S C Whitelaw, S E Cottrell, V A Murday, I P Tomlinson, D Markie, T Jones, D T Bishop, S V Hodgson, D Sheer, J M Northover, I C Talbot, E Solomon, W F Bodmer.   

Abstract

Hereditary mixed polyposis syndrome (HMPS) is characterized by atypical juvenile polyps, colonic adenomas, and colorectal carcinomas. HMPS appears to be inherited in an autosomal dominant manner. Genetic linkage analysis has been performed on a large family with HMPS. Data did not support linkage to the APC locus or to any of the loci for hereditary nonpolyposis colorectal cancer. Evidence that the HMPS locus lies on chromosome 6q was, however, provided by significant two-point LOD scores for linkage between HMPS and the D6S283 locus. Analysis of recombinants and multipoint linkage analysis suggested that the HMPS locus lies in a 4-cM interval containing the D6S283 locus and flanked by markers D6S468 and D6S301.

Entities:  

Mesh：

Year:  1996        PMID： 8644741      PMCID： PMC1914675     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  9 in total

1.  A second-generation linkage map of the human genome.

Authors:  J Weissenbach; G Gyapay; C Dib; A Vignal; J Morissette; P Millasseau; G Vaysseix; M Lathrop
Journal:  Nature       Date:  1992-10-29       Impact factor: 49.962

2.  The 1993-94 Généthon human genetic linkage map.

Authors:  G Gyapay; J Morissette; A Vignal; C Dib; C Fizames; P Millasseau; S Marc; G Bernardi; M Lathrop; J Weissenbach
Journal:  Nat Genet       Date:  1994-06       Impact factor: 38.330

Review 3.  Familial polyposis: recent advances.

Authors:  M Miyaki; K Tanaka; R Kikuchi-Yanoshita; M Muraoka; M Konishi
Journal:  Crit Rev Oncol Hematol       Date:  1995-04       Impact factor: 6.312

4.  Chromosome 5 allele loss in human colorectal carcinomas.

Authors:  E Solomon; R Voss; V Hall; W F Bodmer; J R Jass; A J Jeffreys; F C Lucibello; I Patel; S H Rider
Journal:  Nature       Date:  1987 Aug 13-19       Impact factor: 49.962

Review 5.  Inherited disorders associated with colorectal cancer.

Authors:  V Murday; J Slack
Journal:  Cancer Surv       Date:  1989

Review 6.  Juvenile polyposis.

Authors:  D C Desai; K F Neale; I C Talbot; S V Hodgson; R K Phillips
Journal:  Br J Surg       Date:  1995-01       Impact factor: 6.939

7.  Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse.

Authors:  W F Dietrich; E S Lander; J S Smith; A R Moser; K A Gould; C Luongo; N Borenstein; W Dove
Journal:  Cell       Date:  1993-11-19       Impact factor: 41.582

8.  The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia.

Authors:  M MacPhee; K P Chepenik; R A Liddell; K K Nelson; L D Siracusa; A M Buchberg
Journal:  Cell       Date:  1995-06-16       Impact factor: 41.582

9.  Two simple procedures for releasing chromatin from routinely fixed cells for fluorescence in situ hybridization.

Authors:  H Fidlerová; G Senger; M Kost; P Sanseau; D Sheer
Journal:  Cytogenet Cell Genet       Date:  1994
  9 in total
  14 in total

Review 1.  Hamartomatous polyposis syndromes.

Authors:  Daniel Calva; James R Howe
Journal:  Surg Clin North Am       Date:  2008-08       Impact factor: 2.741

2.  Molecular classification of the inherited hamartoma polyposis syndromes: clearing the muddied waters.

Authors:  C Eng; H Ji
Journal:  Am J Hum Genet       Date:  1998-05       Impact factor: 11.025

Review 3.  The genetics of FAP and FAP-like syndromes.

Authors:  Lara Lipton; Ian Tomlinson
Journal:  Fam Cancer       Date:  2006       Impact factor: 2.375

4.  A gene for familial juvenile polyposis maps to chromosome 18q21.1.

Authors:  J R Howe; J C Ringold; R W Summers; F A Mitros; D Y Nishimura; E M Stone
Journal:  Am J Hum Genet       Date:  1998-05       Impact factor: 11.025

5.  Analysis of genetic and phenotypic heterogeneity in juvenile polyposis.

Authors:  K Woodford-Richens; S Bevan; M Churchman; B Dowling; D Jones; C G Norbury; S V Hodgson; D Desai; K Neale; R K Phillips; J Young; B Leggett; M Dunlop; P Rozen; C Eng; D Markie; M A Rodriguez-Bigas; E Sheridan; T Iwama; D Eccles; G T Smith; J C Kim; K M Kim; J R Sampson; G Evans; S Tejpar; W F Bodmer; I P Tomlinson; R S Houlston
Journal:  Gut       Date:  2000-05       Impact factor: 23.059

Review 6.  Genetics of the hamartomatous polyposis syndromes: a molecular review.

Authors:  Hui-Min Chen; Jing-Yuan Fang
Journal:  Int J Colorectal Dis       Date:  2009-04-21       Impact factor: 2.571

7.  An ancestral Ashkenazi haplotype at the HMPS/CRAC1 locus on 15q13-q14 is associated with hereditary mixed polyposis syndrome.

Authors:  E E M Jaeger; K L Woodford-Richens; M Lockett; A J Rowan; E J Sawyer; K Heinimann; P Rozen; V A Murday; S C Whitelaw; A Ginsberg; W S Atkin; H T Lynch; M C Southey; H Debinski; C Eng; W F Bodmer; I C Talbot; S V Hodgson; H J W Thomas; I P M Tomlinson
Journal:  Am J Hum Genet       Date:  2003-04-14       Impact factor: 11.025

Review 8.  Pathology of the hereditary colorectal carcinoma.

Authors:  Zoran Gatalica; Emina Torlakovic
Journal:  Fam Cancer       Date:  2007-06-13       Impact factor: 2.375

9.  A survey of phenotypic features in juvenile polyposis.

Authors:  D C Desai; V Murday; R K Phillips; K F Neale; P Milla; S V Hodgson
Journal:  J Med Genet       Date:  1998-06       Impact factor: 6.318

10.  Mapping of hereditary mixed polyposis syndrome (HMPS) to chromosome 10q23 by genomewide high-density single nucleotide polymorphism (SNP) scan and identification of BMPR1A loss of function.

Authors:  X Cao; K W Eu; M P Kumarasinghe; H H Li; C Loi; P Y Cheah
Journal:  J Med Genet       Date:  2006-03       Impact factor: 6.318
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.