| Literature DB >> 8641994 |
E Tsukuda1, T Tanaka, K Ochiai, H Kondo, M Yoshida, T Agatsuma, Y Saitoh, S Teshiba, Y Matsuda.
Abstract
EI-1507-1 and -2, novel interleukin-1 beta converting enzyme (ICE) inhibitors, were isolated from the culture broths of Streptomyces sp. E-1507. EI-1507-1 and EI-1507-2 selectively inhibited the recombinant human ICE activity with IC50 values of 0.23 and 0.42 microM, respectively. EI-1507-1 and EI-1507-2 also inhibited mature interleukin-1 beta secretion from THP-1 cells with IC50 values of 1.1 and 1.4 microM, respectively.Entities:
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Year: 1996 PMID： 8641994 DOI： 10.7164/antibiotics.49.333
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649