| Literature DB >> 8641972 |
T Kamoto1, H Shisa, A Pataer, L Lu, O Yoshida, Y Yamada, H Hiai.
Abstract
The effects of two host genes on retrovirus-induced murine lymphoma were evaluated by studying 114 F2 intercross mice between SL/Kh and AKR/Ms mice. Out of 47 T-lymphoma-bearing F2 mice, 45 had the AKR-derived dominant allele at Tism-1. The length of the lymphoma latent period was not related to type of tumor. Instead, it was significantly shortened by a recessive SL/Kh-derived allele at a major histocompatibility complex (MHC)-linked locus on Chr. 17. A quantitative trait analysis of the latent period yielded a maximal logarithm of likelihood ratio for linkage (LOD) score of 7.06 at a class II gene within MHC. The SL/Kh-derived recessive gene was named lla (lymphoma latency acceleration).Entities:
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Year: 1996 PMID： 8641972 PMCID： PMC5921108 DOI： 10.1111/j.1349-7006.1996.tb00236.x
Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050