Literature DB >> 8640742

Anti-tumor activity of the crude saponins obtained from asparagus.

Y Shao1, C K Chin, C T Ho, W Ma, S A Garrison, M T Huang.   

Abstract

The crude saponins from the shoots (edible part of asparagus) of asparagus (asparagus crude saponins; ACS) were found to have antitumor activity. The ACS inhibited the growth of human leukemia HL-60 cells in culture and macromolecular synthesis in a dose and time dependent manner. The ACS at 75-100 micrograms/ml range was cytostatic. ACS concentrations greater than 200 micrograms/ml were cytocidal to HL-60 cells. The ACS at 6 and 50 micrograms/ml inhibited the synthesis of DNA, RNA and protein in HL-60 cells by 41, 5, and 4, respectively, or by 84, 68 and 59%, respectively. The inhibitory effect of ACS on DNA synthesis was irreversible.

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Year:  1996        PMID： 8640742     DOI： 10.1016/0304-3835(96)04233-4

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  9 in total

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3.  Bioactive compounds, antioxidant and binding activities and spear yield of Asparagus officinalis L.

Authors:  Jong Won Lee; Jeong Hyun Lee; In Ho Yu; Shela Gorinstein; Jong Hyang Bae; Yang Gyu Ku
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4.  Anticancer effects of deproteinized asparagus polysaccharide on hepatocellular carcinoma in vitro and in vivo.

Authors:  Jianfeng Xiang; Yanjie Xiang; Shengming Lin; Dongwei Xin; Xiaoyu Liu; Lingling Weng; Tao Chen; Minguang Zhang
Journal:  Tumour Biol       Date:  2013-12-06

5.  Phytochemical and toxicological investigations of crude methanolic extracts, subsequent fractions and crude saponins of Isodon rugosus.

Authors:  Anwar Zeb; Abdul Sadiq; Farhat Ullah; Sajjad Ahmad; Muhammad Ayaz
Journal:  Biol Res       Date:  2014-11-06       Impact factor: 5.612

6.  The Impacts of Asparagus Extract Fractions on Growth and Fumonisins Biosynthesis in Fusarium Proliferatum.

Authors:  Natalia Witaszak; Justyna Lalak-Kańczugowska; Agnieszka Waśkiewicz; Łukasz Stępień
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7.  Effect of Spinach, a High Dietary Nitrate Source, on Arterial Stiffness and Related Hemodynamic Measures: A Randomized, Controlled Trial in Healthy Adults.

Authors:  Elena Jovanovski; Laura Bosco; Kashif Khan; Fei Au-Yeung; Hoang Ho; Andreea Zurbau; Alexandra L Jenkins; Vladimir Vuksan
Journal:  Clin Nutr Res       Date:  2015-07-31

8.  Methanolic extract of white asparagus shoots activates TRAIL apoptotic death pathway in human cancer cells and inhibits colon carcinogenesis in a preclinical model.

Authors:  Souad Bousserouel; Julie Le Grandois; Francine Gossé; Dalal Werner; Stephan W Barth; Eric Marchioni; Jacques Marescaux; Francis Raul
Journal:  Int J Oncol       Date:  2013-06-07       Impact factor: 5.650

Review 9.  Green and White Asparagus (Asparagus officinalis): A Source of Developmental, Chemical and Urinary Intrigue.

Authors:  Eirini Pegiou; Roland Mumm; Parag Acharya; Ric C H de Vos; Robert D Hall
Journal:  Metabolites       Date:  2019-12-25
  9 in total

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