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Literature DB >> 8633880

Enhanced production of succinic acid by overexpression of phosphoenolpyruvate carboxylase in Escherichia coli.

C S Millard¹, Y P Chao, J C Liao, M I Donnelly.

Abstract

Fermentative production of succinic acid from glucose by Escherichia coli was significantly increased by overexpression of phosphoenolpyruvate carboxylase. In contrast, overexpression of phosphoenolpyruvate carboxykinase had no effect. Under optimized conditions, induction of the carboxylase resulted in a 3.5-fold increase in the concentration of succinic acid, making succinic acid the major fermentation product by weight.

Entities: Chemical Gene Species

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Year: 1996 PMID： 8633880 PMCID： PMC167956 DOI： 10.1128/aem.62.5.1808-1810.1996

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

18 in total

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Authors: N S Samuelov; R Lamed; S Lowe; J G Zeikus
Journal: Appl Environ Microbiol Date: 1991-10 Impact factor: 4.792

Review 2. The fermentation pathways of Escherichia coli.

Authors: D P Clark
Journal: FEMS Microbiol Rev Date: 1989-09 Impact factor: 16.408

3. Regulatory mechanisms involving nicotinamide adenine nucleotides as all teric effectors. II. Control of phosphoenolpyruvate carboxykinase.

Authors: J A Wright; B D Sanwal
Journal: J Biol Chem Date: 1969-04-10 Impact factor: 5.157

4. Allosteric control by calcium and mechanism of desensitization of phosphoenolpyruvate carboxykinase of Escherichia coli.

Authors: A H Goldie; B D Sanwal
Journal: J Biol Chem Date: 1980-02-25 Impact factor: 5.157

5. The kinetic properties of phosphoenolpyruvate carboxykinase of Escherichia coli.

Authors: A Krebs; W A Bridger
Journal: Can J Biochem Date: 1980-04

6. On the monomeric structure and proposed regulatory properties of phosphoenolpyruvate carboxykinase of Escherichia coli.

Authors: A Krebs; W A Bridger
Journal: Can J Biochem Date: 1976-01

7. New approach to the cultivation of methanogenic bacteria: 2-mercaptoethanesulfonic acid (HS-CoM)-dependent growth of Methanobacterium ruminantium in a pressureized atmosphere.

Authors: W E Balch; R S Wolfe
Journal: Appl Environ Microbiol Date: 1976-12 Impact factor: 4.792

8. Molecular cloning of the plasmid RP4 primase region in a multi-host-range tacP expression vector.

Authors: J P Fürste; W Pansegrau; R Frank; H Blöcker; P Scholz; M Bagdasarian; E Lanka
Journal: Gene Date: 1986 Impact factor: 3.688

9. Purification and characterization of phosphoenolpyruvate carboxykinase,a catabolic CO2-fixing enzyme, from Anaerobiospirillum succiniciproducens.

Authors: S M Podkovyrov; J G Zeikus
Journal: J Gen Microbiol Date: 1993-02

10. Alteration of growth yield by overexpression of phosphoenolpyruvate carboxylase and phosphoenolpyruvate carboxykinase in Escherichia coli.

Authors: Y P Chao; J C Liao
Journal: Appl Environ Microbiol Date: 1993-12 Impact factor: 4.792

42 in total

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Journal: Appl Environ Microbiol Date: 2013-06-07 Impact factor: 4.792

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4. Effects of growth mode and pyruvate carboxylase on succinic acid production by metabolically engineered strains of Escherichia coli.

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5. Effect of carbon sources differing in oxidation state and transport route on succinate production in metabolically engineered Escherichia coli.

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6. Succinic acid production with Actinobacillus succinogenes ZT-130 in the presence of succinic acid.

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Journal: Curr Microbiol Date: 2009-09-24 Impact factor: 2.188

7. Reengineering Escherichia coli for Succinate Production in Mineral Salts Medium.

Authors: X Zhang; K Jantama; K T Shanmugam; L O Ingram
Journal: Appl Environ Microbiol Date: 2009-10-16 Impact factor: 4.792

8. Improved succinic acid production in the anaerobic culture of an Escherichia coli pflB ldhA double mutant as a result of enhanced anaplerotic activities in the preceding aerobic culture.

Authors: Hui Wu; Zhi-Min Li; Li Zhou; Qin Ye
Journal: Appl Environ Microbiol Date: 2007-10-19 Impact factor: 4.792

9. OptForce: an optimization procedure for identifying all genetic manipulations leading to targeted overproductions.

Authors: Sridhar Ranganathan; Patrick F Suthers; Costas D Maranas
Journal: PLoS Comput Biol Date: 2010-04-15 Impact factor: 4.475

10. Metabolic engineering of a novel propionate-independent pathway for the production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in recombinant Salmonella enterica serovar typhimurium.

Authors: Ilana S Aldor; Seon-Won Kim; Kristala L Jones Prather; Jay D Keasling
Journal: Appl Environ Microbiol Date: 2002-08 Impact factor: 4.792