Literature DB >> 8631728

The drug-binding activity of the multidrug-responding transcriptional regulator BmrR resides in its C-terminal domain.

P N Markham1, M Ahmed, A A Neyfakh.   

Abstract

Rhodamine and tetraphenylphosphonium, the substrates of the Bacillus subtilis multidrug efflux transporter Bmr, induce the expression of Bmr through direct interaction with its transcriptional activator BmrR. Here we show that the C-terminal domain of BmrR, expressed individually, binds both these compounds and therefore can be used as a model for molecular analysis of the phenomenon of multidrug recognition.

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Year:  1996        PMID： 8631728      PMCID： PMC177825          DOI： 10.1128/jb.178.5.1473-1475.1996

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  10 in total

Review 1.  Untwist and shout: a heavy metal-responsive transcriptional regulator.

Authors:  A O Summers
Journal:  J Bacteriol       Date:  1992-05       Impact factor: 3.490

2.  Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system.

Authors:  A A Neyfakh; V E Bidnenko; L B Chen
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-01       Impact factor: 11.205

Review 3.  Multidrug resistance pumps in bacteria: variations on a theme.

Authors:  K Lewis
Journal:  Trends Biochem Sci       Date:  1994-03       Impact factor: 13.807

Review 4.  Biochemistry of multidrug resistance mediated by the multidrug transporter.

Authors:  M M Gottesman; I Pastan
Journal:  Annu Rev Biochem       Date:  1993       Impact factor: 23.643

Review 5.  Prevention of drug access to bacterial targets: permeability barriers and active efflux.

Authors:  H Nikaido
Journal:  Science       Date:  1994-04-15       Impact factor: 47.728

6.  A protein that activates expression of a multidrug efflux transporter upon binding the transporter substrates.

Authors:  M Ahmed; C M Borsch; S S Taylor; N Vázquez-Laslop; A A Neyfakh
Journal:  J Biol Chem       Date:  1994-11-11       Impact factor: 5.157

7.  A thioredoxin gene fusion expression system that circumvents inclusion body formation in the E. coli cytoplasm.

Authors:  E R LaVallie; E A DiBlasio; S Kovacic; K L Grant; P F Schendel; J M McCoy
Journal:  Biotechnology (N Y)       Date:  1993-02

8.  Two highly similar multidrug transporters of Bacillus subtilis whose expression is differentially regulated.

Authors:  M Ahmed; L Lyass; P N Markham; S S Taylor; N Vázquez-Laslop; A A Neyfakh
Journal:  J Bacteriol       Date:  1995-07       Impact factor: 3.490

9.  The MerR metalloregulatory protein binds mercuric ion as a tricoordinate, metal-bridged dimer.

Authors:  J D Helmann; B T Ballard; C T Walsh
Journal:  Science       Date:  1990-02-23       Impact factor: 47.728

10.  Autogenous transcriptional activation of a thiostrepton-induced gene in Streptomyces lividans.

Authors:  D J Holmes; J L Caso; C J Thompson
Journal:  EMBO J       Date:  1993-08       Impact factor: 11.598
  10 in total
  12 in total

1.  Purification and ligand binding of EmrR, a regulator of a multidrug transporter.

Authors:  A Brooun; J J Tomashek; K Lewis
Journal:  J Bacteriol       Date:  1999-08       Impact factor: 3.490

Review 2.  Molecular properties of bacterial multidrug transporters.

Authors:  M Putman; H W van Veen; W N Konings
Journal:  Microbiol Mol Biol Rev       Date:  2000-12       Impact factor: 11.056

3.  The staphylococcal QacR multidrug regulator binds a correctly spaced operator as a pair of dimers.

Authors:  S Grkovic; M H Brown; M A Schumacher; R G Brennan; R A Skurray
Journal:  J Bacteriol       Date:  2001-12       Impact factor: 3.490

Review 4.  Distribution and physiology of ABC-type transporters contributing to multidrug resistance in bacteria.

Authors:  Jacek Lubelski; Wil N Konings; Arnold J M Driessen
Journal:  Microbiol Mol Biol Rev       Date:  2007-09       Impact factor: 11.056

Review 5.  Proton-dependent multidrug efflux systems.

Authors:  I T Paulsen; M H Brown; R A Skurray
Journal:  Microbiol Rev       Date:  1996-12

6.  Identification of the High-affinity Substrate-binding Site of the Multidrug and Toxic Compound Extrusion (MATE) Family Transporter from Pseudomonas stutzeri.

Authors:  Laiyin Nie; Ernst Grell; Viveka Nand Malviya; Hao Xie; Jingkang Wang; Hartmut Michel
Journal:  J Biol Chem       Date:  2016-05-27       Impact factor: 5.157

7.  Investigation of ligand binding to the multidrug resistance protein EmrE by isothermal titration calorimetry.

Authors:  Curtis W Sikora; Raymond J Turner
Journal:  Biophys J       Date:  2004-10-22       Impact factor: 4.033

Review 8.  Regulation of bacterial drug export systems.

Authors:  Steve Grkovic; Melissa H Brown; Ronald A Skurray
Journal:  Microbiol Mol Biol Rev       Date:  2002-12       Impact factor: 11.056

9.  Bile salts modulate expression of the CmeABC multidrug efflux pump in Campylobacter jejuni.

Authors:  Jun Lin; Cédric Cagliero; Baoqing Guo; Yi-Wen Barton; Marie-Christine Maurel; Sophie Payot; Qijing Zhang
Journal:  J Bacteriol       Date:  2005-11       Impact factor: 3.490

10.  Crystal structures of multidrug binding protein TtgR in complex with antibiotics and plant antimicrobials.

Authors:  Yilmaz Alguel; Cuixiang Meng; Wilson Terán; Tino Krell; Juan L Ramos; María-Trinidad Gallegos; Xiaodong Zhang
Journal:  J Mol Biol       Date:  2007-03-30       Impact factor: 5.469
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