BACKGROUND: Malignant mesenchymomas are rare soft tissue tumors that contain two or more distinct histologic subtypes of sarcoma within the same tumor (exclusive of a fibrosarcomatous or hemangiopericytomatous component). They are generally considered high grade neoplasms and are associated with a poor prognosis, although experience with these tumors is limited. METHODS: We report 8 patients seen at our center over the last 22 years and describe the clinical course of a patient with a malignant mesenchymoma arising in the retroperitoneum whose experience typifies the aggressive behavior of this tumor. RESULTS: All eight patients had large, high grade tumors located in the retroperitoneum or thigh. Six of the 8 died of disease and 2 were alive with disease at a median of 30 months from diagnosis. CONCLUSIONS: Malignant mesenchymoma represents a particularly aggressive form of soft tissue sarcoma. Our experience with this disease highlights the need for more effective treatment strategies for these patients.
BACKGROUND:Malignant mesenchymomas are rare soft tissue tumors that contain two or more distinct histologic subtypes of sarcoma within the same tumor (exclusive of a fibrosarcomatous or hemangiopericytomatous component). They are generally considered high grade neoplasms and are associated with a poor prognosis, although experience with these tumors is limited. METHODS: We report 8 patients seen at our center over the last 22 years and describe the clinical course of a patient with a malignant mesenchymoma arising in the retroperitoneum whose experience typifies the aggressive behavior of this tumor. RESULTS: All eight patients had large, high grade tumors located in the retroperitoneum or thigh. Six of the 8 died of disease and 2 were alive with disease at a median of 30 months from diagnosis. CONCLUSIONS:Malignant mesenchymoma represents a particularly aggressive form of soft tissue sarcoma. Our experience with this disease highlights the need for more effective treatment strategies for these patients.
Authors: Florian Grabellus; Sien-Yi Sheu; Boris Schmidt; Michael Flasshove; Cornelius Kuhnen; Steffen Ruchholtz; Georg Taeger; Kurt Werner Schmid Journal: Virchows Arch Date: 2005-10-14 Impact factor: 4.064
Authors: Jung Eun Choi; Hong Jun Chung; Won Jong Yoo; Myung Hee Chung; Mi Sook Sung; Hae Giu Lee; Il Young Park; Jeana Kim Journal: Korean J Radiol Date: 2002 Oct-Dec Impact factor: 3.500
Authors: Monika Bekiesinska-Figatowska; Agnieszka Duczkowska; Marek Duczkowski; Hanna Bragoszewska; Anna Romaniuk-Doroszewska; Beata Iwanowska; Sylwia Szkudlinska-Pawlak; Jaroslaw Madzik; Katarzyna Bilska; Anna Raciborska Journal: Biomed Res Int Date: 2017-01-24 Impact factor: 3.411